Comparing morphological and secretory aspects of cephalic glands among the New World coral snakes brings novel insights on their biological roles

Full metadata record
DC FieldValueLanguage
dc.contributor(CeTICS) Centro de Toxinas, Resposta-imune e Sinalização Celularpt_BR
dc.contributor(LG) Lab. Genéticapt_BR
dc.contributorLab. Coleções Zoológicaspt_BR
dc.contributorPrograma de Pós-Doutoradopt_BR
dc.contributorPrograma de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.authorOliveira, Leonardopt_BR
dc.contributor.authorNachtigall, Pedro Gabrielpt_BR
dc.contributor.authorVialla, Vincent Louispt_BR
dc.contributor.authorCampos, Pollyanna Fernandespt_BR
dc.contributor.authorCosta-Neves, Adrianapt_BR
dc.contributor.authorZaher, Hussampt_BR
dc.contributor.authorda Silva Jr., Nelson Jorgept_BR
dc.contributor.authorGrazziotin, Felipe Gobbipt_BR
dc.contributor.authorWilkinson, Markpt_BR
dc.contributor.authorJunqueira-de-Azevedo, Inácio de Loiola Meirellespt_BR
dc.date.accessioned2023-11-14T17:46:26Z-
dc.date.available2023-11-14T17:46:26Z-
dc.date.issued2023pt_BR
dc.identifier.citationOliveira L, Nachtigall PG, Vialla VL, Campos PF, Costa-Neves A, Zaher H, et al. Comparing morphological and secretory aspects of cephalic glands among the New World coral snakes brings novel insights on their biological roles. Toxicon. . doi:10.1016/j.toxicon.2023.107285.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/5142-
dc.description.abstractOral and other cephalic glands have been surveyed by several studies with distinct purposes. Despite the wide diversity and medical relevance of the New World coral snakes, studies focusing on understanding the biological roles of the glands within this group are still scarce. Specifically, the venom glands of some coral snakes were previously investigated but all other cephalic glands remain uncharacterized. In this sense, performing morphological and molecular analysis of these glands may help better understand their biological role. Here, we studied the morphology of the venom, infralabial, rictal, and harderian glands of thirteen species of Micrurus and Micruroides euryxanthus. We also performed a molecular characterization of these glands from selected species of Micrurus using transcriptomic and proteomic approaches. We described substantial morphological variation in the cephalic glands of New World coral snakes and structural evidence for protein-secreting cells in the inferior rictal glands. Our molecular analysis revealed that the venom glands, as expected, are majorly devoted to toxin production, however, the infralabial and inferior rictal glands also expressed some toxin genes at low to medium levels, despite the marked morphological differences. On the other hand, the harderian glands were dominated by the expression of lipocalins, but do not produce toxins. Our integrative analysis, including the prediction of biological processes and pathways, helped decipher some important traits of cephalic glands and better understand their biology.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.extent107285pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxiconpt_BR
dc.rightsRestricted accesspt_BR
dc.titleComparing morphological and secretory aspects of cephalic glands among the New World coral snakes brings novel insights on their biological rolespt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.toxicon.2023.107285pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.toxicon.2023.107285pt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.external(PUC-GO) Pontifícia Universidade Católica de Goiáspt_BR
dc.subject.keywordvenom glandspt_BR
dc.subject.keywordinfralabial glandspt_BR
dc.subject.keywordrictal glandspt_BR
dc.subject.keywordharderian glandspt_BR
dc.subject.keywordfront-fanged snakespt_BR
dc.subject.keywordmicro-CT scanpt_BR
dc.relation.ispartofabbreviatedToxiconpt_BR
dc.contributor.butantanOliveira, Leonardo|*pt_BR
dc.contributor.butantanNachtigall, Pedro Gabriel|:Pós-Doc|:(CeTICS) Centro de Toxinas, Resposta-imune e Sinalização Celular|:Programa de Pós-Doutoradopt_BR
dc.contributor.butantanCampos, Pollyanna Fernandes|:Técnico|:Egresso Pós-Doc|:(CeTICS) Centro de Toxinas, Resposta-imune e Sinalização Celular|:pt_BR
dc.contributor.butantanCosta-Neves, Adriana|:Pesquisador|:(LG) Lab. Genética|:pt_BR
dc.contributor.butantanGrazziotin, Felipe Gobbi|:Outros|Docente PPGTOX|:Lab. Coleções Zoológicas|:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.butantanJunqueira-de-Azevedo, Inácio de Loiola Meirelles|:Pesquisador|:(CeTICS) Centro de Toxinas, Resposta-imune e Sinalização Celular|:pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2017/25089-5pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/09301-7pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/26520-4pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2016/50127-5pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦314287/2020-5pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.languageiso639-1English-
item.openairetypeArticle-
crisitem.journal.journalissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journaleissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid0000-0002-3006-9194-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid0000-0001-9896-9722-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid0000-0003-4491-0180-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
Appears in Collections:Artigos


Files in This Item:

1-s2.0-S0041010123002714-main.pdf
Description:
Size: 15.79 MB
Format: Adobe PDF
View/Open
Show simple item record

The access to the publications deposited in this repository respects the licenses from journals and publishers.