Epidemiological and genomic analysis of asymptomatic SARS-CoV-2 infections during the delta and omicron epidemic waves in São Paulo City, Brazil

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dc.contributorCeVIVASpt_BR
dc.contributor(LCC) Lab. Ciclo Celularpt_BR
dc.contributor(LEDM) Lab. Estratégico de Diagnóstico Molecularpt_BR
dc.contributorLab. Fisiopatologiapt_BR
dc.contributorDiretoria Técnicapt_BR
dc.contributorPrograma de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.authorSlavov, Svetoslav Nanevpt_BR
dc.contributor.authorLima, Alex Ranieri Jerônimopt_BR
dc.contributor.authorRibeiro, Gabrielapt_BR
dc.contributor.authorLima, Loyze Paola Oliveira dept_BR
dc.contributor.authorBarros, Claudia Renata dos Santospt_BR
dc.contributor.authorMarqueze, Elaine Cristinapt_BR
dc.contributor.authorMartins, Antonio Jorgept_BR
dc.contributor.authorSampaio, Sandra Coccuzzopt_BR
dc.contributor.authorElias, Maria Carolinapt_BR
dc.date.accessioned2023-12-07T19:07:00Z-
dc.date.available2023-12-07T19:07:00Z-
dc.date.issued2023pt_BR
dc.identifier.citationSlavov SN, Lima ARJ, Ribeiro G, Lima LPO, Barros CRS, Marqueze EC, et al. Epidemiological and genomic analysis of asymptomatic SARS-CoV-2 infections during the delta and omicron epidemic waves in São Paulo City, Brazil. Viruses. 2023, Nov; 15, 11: 123420. doi:10.3390/v15112210.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/5174-
dc.description.abstractWe examined the asymptomatic rates of SARS-CoV-2 infection during the Delta and Omicron waves in the city of São Paulo. Nasopharyngeal swabs were collected at strategic points of the city (open-air markets, bus terminals, airports) for SARS-CoV-2 RNA testing. Applying the questionnaire, the symptomatic individuals were excluded, and only asymptomatic cases were analyzed. During the Delta wave, a total of 4315 samples were collected, whereas 2372 samples were collected during the first Omicron wave. The incidence of the asymptomatic SARS-CoV-2 infection was 0.6% during the Delta wave and 0.8% during the Omicron wave. No statistical differences were found in the threshold amplification cycle. However, there was a statistical difference observed in the sublineage distribution between asymptomatic and symptomatic individuals. Our study determined the incidence of asymptomatic infection by monitoring individuals who remained symptom-free, thereby providing a reliable evaluation of asymptomatic SARS-CoV-2 carriage. Our findings reveal a relatively low proportion of asymptomatic cases, which could be attributed to our rigorous monitoring protocol for the presence of clinical symptoms. Investigating asymptomatic infection rates is crucial to develop and implement effective disease control strategiespt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(NIH) National Institutes of Healthpt_BR
dc.format.extent2210pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofVirusespt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleEpidemiological and genomic analysis of asymptomatic SARS-CoV-2 infections during the delta and omicron epidemic waves in São Paulo City, Brazilpt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3390/v15112210pt_BR
dc.contributor.externalRibeirão Preto Medical Schoolpt_BR
dc.contributor.external(FHRP) Fundação Hemocentro de Ribeirão Pretopt_BR
dc.contributor.external(COVISA) Coordenadoria de Vigilância em Saúdept_BR
dc.contributor.externalSecretaria Municipal da Saúde da Prefeitura da Cidade de São Paulopt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.external(UFMG) Universidade Federal de Minas Geraispt_BR
dc.contributor.external(FIOCRUZ) Fundação Oswaldo Cruzpt_BR
dc.contributor.externalUniversity Campus Bio-Medico of Romept_BR
dc.identifier.citationvolume15pt_BR
dc.identifier.citationissue11pt_BR
dc.subject.keywordasymptomatic infectionpt_BR
dc.subject.keywordSARS-CoV-2pt_BR
dc.subject.keywordepidemiologypt_BR
dc.subject.keywordmolecular testingpt_BR
dc.subject.keywordgenomic surveillancept_BR
dc.subject.keywordBrazilpt_BR
dc.relation.ispartofabbreviatedVirusespt_BR
dc.identifier.citationabntv.15, n. 11, 2210, nov. 2023pt_BR
dc.identifier.citationvancouver2023, Nov; 15, 11: 123420pt_BR
dc.contributor.butantanSlavov, Svetoslav Nanev|:Pesquisador|:(LCC) Lab. Ciclo Celular|:PrimeiroAutorpt_BR
dc.contributor.butantanLima, Alex Ranieri Jerônimo|:Pesquisador|:(LCC) Lab. Ciclo Celularpt_BR
dc.contributor.butantanRibeiro, Gabriela|:Técnico|:(LCC) Lab. Ciclo Celularpt_BR
dc.contributor.butantanLima, Loyze Paola Oliveira de|:Técnico|:(LEDM) Lab. Estratégico de Diagnóstico Molecularpt_BR
dc.contributor.butantanBarros, Claudia Renata dos Santos|:Outros|:CeVIVASpt_BR
dc.contributor.butantanMarqueze, Elaine Cristina|:Outros|:CeVIVASpt_BR
dc.contributor.butantanMartins, Antonio Jorge|:Pesquisador|:Diretoria Técnicapt_BR
dc.contributor.butantanSampaio, Sandra Coccuzzo|:Pesquisador|:Docente|:Lab. Fisiopatologia|:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)|:Autor de correspondênciapt_BR
dc.contributor.butantanElias, Maria Carolina|:Pesquisador|:(LCC) Lab. Ciclo Celular|:Autor de correspondênciapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2020/10127-1pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2021/11944-6pt_BR
dc.sponsorship.butantan(NIH) National Institutes of Health¦¦U01 AI151698pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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item.languageiso639-1English-
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