Venom composition of neglected Bothropoid snakes from the Amazon Rainforest: ecological and toxinological implications

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dc.contributorLab. Imunopatologiapt_BR
dc.contributor(LETA) Lab. Toxinologia Aplicadapt_BR
dc.contributorLab. Coleções Zoológicaspt_BR
dc.contributorPrograma de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.authorFreitas-de-Sousa, Luciana Aparecidapt_BR
dc.contributor.authorColombini, Mônicapt_BR
dc.contributor.authorSouza, Vinicius Carius dept_BR
dc.contributor.authorSerrano, Solange Maria de Toledopt_BR
dc.contributor.authorJunqueira-de-Azevedo, Inácio de Loiola Meirellespt_BR
dc.contributor.authorGrazziotin, Felipe Gobbipt_BR
dc.contributor.authorMoura-da-Silva, Ana Mariapt_BR
dc.date.accessioned2024-02-29T18:52:52Z-
dc.date.available2024-02-29T18:52:52Z-
dc.date.issued2024pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/5266-
dc.description.abstractSnake venoms have evolved in several families of Caenophidae, and their toxins have been assumed to be biochemical weapons with a role as a trophic adaptation. However, it remains unclear how venom contributes to the success of venomous species for adaptation to different environments. Here we compared the venoms from Bothrocophias hyoprora, Bothrops taeniatus, Bothrops bilineatus smaragdinus, Bothrops brazili, and Bothrops atrox collected in the Amazon Rainforest, aiming to understand the ecological and toxinological consequences of venom composition. Transcriptomic and proteomic analyses indicated that the venoms presented the same toxin groups characteristic from bothropoids, but with distinct isoforms with variable qualitative and quantitative abundances, contributing to distinct enzymatic and toxic effects. Despite the particularities of each venom, commercial Bothrops antivenom recognized the venom components and neutralized the lethality of all species. No clear features could be observed between venoms from arboreal and terrestrial habitats, nor in the dispersion of the species throughout the Amazon habitats, supporting the notion that venom composition may not shape the ecological or toxinological characteristics of these snake species and that other factors influence their foraging or dispersal in different ecological niches.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship(FAPEAM) Fundação de Amparo à Pesquisa do Estado do Amazonaspt_BR
dc.format.extent83pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxinspt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleVenom composition of neglected Bothropoid snakes from the Amazon Rainforest: ecological and toxinological implicationspt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3390/toxins16020083pt_BR
dc.contributor.external(IFAC) Instituto Federal do Acrept_BR
dc.contributor.external(UFAC) Universidade Federal do Acrept_BR
dc.contributor.external(FMT-HVD) Fundação de Medicina Tropical Doutor Heitor Vieira Douradopt_BR
dc.identifier.citationvolume16pt_BR
dc.identifier.citationissue2pt_BR
dc.subject.keywordsnake venomspt_BR
dc.subject.keywordtranscriptomicspt_BR
dc.subject.keywordproteomicspt_BR
dc.subject.keywordantivenompt_BR
dc.subject.keywordAmazonpt_BR
dc.subject.keywordBothropspt_BR
dc.subject.keywordBothrocophiaspt_BR
dc.relation.ispartofabbreviatedToxinspt_BR
dc.identifier.citationabntv. 16, n. 2, 83, fev. 2024pt_BR
dc.identifier.citationvancouver2024 Feb; 16(2):83pt_BR
dc.contributor.butantanFreitas-de-Sousa, Luciana Aparecida|:Técnico|:Lab. Imunopatologia|:PrimeiroAutorpt_BR
dc.contributor.butantanColombini, Mônica|:Técnico|:Lab. Imunopatologiapt_BR
dc.contributor.butantanSerrano, Solange Maria de Toledo|:Pesquisador|:(LETA) Lab. Toxinologia Aplicadapt_BR
dc.contributor.butantanJunqueira-de-Azevedo, Inácio de Loiola Meirelles|:Pesquisador|:(LETA) Lab. Toxinologia Aplicadapt_BR
dc.contributor.butantanGrazziotin, Felipe Gobbi|:Pesquisador|:Docente PPGTOX|:Lab. Coleções Zoológicas|:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox):Autor de correspondênciapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2022/10344-8pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2016/50127-5pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2013/07467-1pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2021/13939pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2022/12660-4pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦303958/2018-9pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦304532/2013pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦311509/2020-7pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦312016/2021-2pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦405518/2021-8pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦311434/2021–5pt_BR
dc.sponsorship.butantan(FAPEAM) Fundação de Amparo à Pesquisa do Estado do Amazonas¦¦01.02.016301.03340/2021-69pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦401519/2023-6pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextopen-
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