Global proteome of the saprophytic strain Leptospira biflexa and comparative analysis with pathogenic strain Leptospira interrogans uncover new pathogenesis mechanisms

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dc.contributorLab. Bioquímicapt_BR
dc.contributor(LDV) Lab. Desenvolvimento de Vacinaspt_BR
dc.contributorPrograma de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.authorFilho, Edson G. Nascimentopt_BR
dc.contributor.authorVieira, Mônica L.pt_BR
dc.contributor.authorDias, Meriellenpt_BR
dc.contributor.authorMendes, Maria A.pt_BR
dc.contributor.authorSanchez, Fabio B.pt_BR
dc.contributor.authorSetubal, João C.pt_BR
dc.contributor.authorHeinemann, Marcos B.pt_BR
dc.contributor.authorSouza, Gisele O.pt_BR
dc.contributor.authorPimenta, Daniel Carvalhopt_BR
dc.contributor.authorNascimento, Ana Lúcia Tabet Ollerpt_BR
dc.date.accessioned2024-03-14T18:56:39Z-
dc.date.available2024-03-14T18:56:39Z-
dc.date.issued2024pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/5273-
dc.description.abstractLeptospira is a genus of bacteria that includes free-living saprophytic species found in water or soil, and pathogenic species, which are the etiologic agents of leptospirosis. Besides all the efforts, there are only a few proteins described as virulence factors in the pathogenic strain L. interrogans. This work aims to perform L. biflexa serovar Patoc1 strain Paris global proteome and to compare with the proteome database of pathogenic L. interrogans serovar Copenhageni strain Fiocruz L1–130. We identified a total of 2327 expressed proteins of L. biflexa by mass spectrometry. Using the Get Homologues software with the global proteome of L. biflexa and L. interrogans, we found orthologous proteins classified into conserved, low conserved, and specific proteins. Comparative bioinformatic analyses were performed to understand the biological functions of the proteins, subcellular localization, the presence of signal peptide, structural domains, and motifs using public softwares. These results lead to the selection of 182 low conserved within the saprophyte, and 176 specific proteins of L. interrogans. It is anticipated that these findings will indicate further studies to uncover virulence factors in the pathogenic strain. This work presents for the first time the global proteome of saprophytic strain L. biflexa serovar Patoc, strain Patoc1.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship(FINEP) Financiadora de Estudos e Projetospt_BR
dc.description.sponsorship(FAPEMIG) Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.extent105125pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofJournal of Proteomicspt_BR
dc.rightsRestricted accesspt_BR
dc.titleGlobal proteome of the saprophytic strain Leptospira biflexa and comparative analysis with pathogenic strain Leptospira interrogans uncover new pathogenesis mechanismspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.jprot.2024.105125pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.jprot.2024.105125pt_BR
dc.contributor.external(UFMG) Universidade Federal de Minas Geraispt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.identifier.citationvolume297pt_BR
dc.subject.keywordLeptospira biflexapt_BR
dc.subject.keywordLeptospira interroganspt_BR
dc.subject.keywordComparative proteomic analysespt_BR
dc.subject.keywordVirulencept_BR
dc.subject.keywordPathogenesispt_BR
dc.subject.keywordAnd leptospirosispt_BR
dc.relation.ispartofabbreviatedJ Proteomicspt_BR
dc.identifier.citationabntv. 297, 105125, abr. 2024pt_BR
dc.identifier.citationvancouver2024 Apr; 297:105125pt_BR
dc.contributor.butantanPimenta, Daniel Carvalho|:Pesquisador|:Docente PPGTOX|:Lab. Bioquímica|:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.butantanNascimento, Ana Lúcia Tabet Oller|:Pesquisador|:(LDV) Lab. Desenvolvimento de Vacinas|:Autor de correspondênciapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019/17488–2pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦ 2018/06201–1pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2013/50218–2pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦304445/2021–5pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦301974/2019–5pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦405925/2021–2pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦305961/2019–5pt_BR
dc.sponsorship.butantan(FINEP) Financiadora de Estudos e Projetos¦¦01.09.0278.00pt_BR
dc.sponsorship.butantan(FAPEMIG) Fundação de Amparo à Pesquisa do Estado de Minas Gerais¦¦APQ-00121-21pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
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