Profiling the linear peptides of venom from the Brazilian scorpion Tityus serrulatus: structural and functional characterization

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dc.contributorLab. Farmacologiapt_BR
dc.contributor.authorDias, Nathalia Baptistapt_BR
dc.contributor.authorSouza, Bibiana Monson dept_BR
dc.contributor.authorCid-Alda, Fernandapt_BR
dc.contributor.authorDorce, Valquiria Abrão Coronadopt_BR
dc.contributor.authorCocchi, Fernando Kamimurapt_BR
dc.contributor.authorPalma, Mario Sergiopt_BR
dc.date.accessioned2024-03-26T13:36:46Z-
dc.date.available2024-03-26T13:36:46Z-
dc.date.issued2024pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/5297-
dc.description.abstractScorpion venoms are a rich source of bioactive peptides, most of which are neurotoxic, with 30 to 70 amino acid residues in their sequences. There are a scarcity of reports in the literature concerning the short linear peptides found in scorpion venoms. This type of peptide toxin may be selectively extracted from the venom using 50% (v/v) acetonitrile. The use of LC-MS and MS/MS enabled the detection of 12 bioactive short linear peptides, of which six were identified as cryptides. These peptides were shown to be multifunctional, causing hemolysis, mast cell degranulation and lysis, edema, pain, and anxiety, increasing the complexity of the envenomation mechanism. Apparently, the natural functions of these peptide toxins are to induce inflammation and discomfort in the victims of scorpion stings.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.extent480-490pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofJournal of Natural Productspt_BR
dc.rightsRestricted accesspt_BR
dc.titleProfiling the linear peptides of venom from the Brazilian scorpion Tityus serrulatus: structural and functional characterizationpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1021/acs.jnatprod.3c01085pt_BR
dc.identifier.urlhttps://doi.org/10.1021/acs.jnatprod.3c01085pt_BR
dc.contributor.externalUniversidad de La Fronterapt_BR
dc.contributor.external(UNESP) Universidade Estadual Paulista Júlio de Mesquita Filhopt_BR
dc.identifier.citationvolume87pt_BR
dc.identifier.citationissue3pt_BR
dc.relation.ispartofabbreviatedJ Nat Prodpt_BR
dc.identifier.citationabntv. 87, n. 3, p. 480-490pt_BR
dc.identifier.citationvancouver2024 Feb; 87(3):480-490pt_BR
dc.contributor.butantanDorce, Valquiria Abrão Coronado|:Pesquisador|:Lab. Farmacologiapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2011/51684-1pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦1207/2011pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦1208/2011pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦1208/20111230/2011pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦PIA21-0002pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦2011/51684-1pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.fulltextSem Texto completo-
item.languageiso639-1English-
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