B-1 cells upregulate CD8 T lymphocytes and increase proinflammatory cytokines serum levels in oral encephalitozoonosis

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dc.contributorLaboratório de Fisiopatologiapt_BR
dc.contributor.authorSantos, Denise Langanke dospt_BR
dc.contributor.authorAlvares-Saraiva, Anuska Marcelinopt_BR
dc.contributor.authorXavier, José Guilhermept_BR
dc.contributor.authorSpadacci-Morena, Diva Denellept_BR
dc.contributor.authorPeres, Giovani Bravinpt_BR
dc.contributor.authorRocha, Paulo Ricardo Dell'Armelinapt_BR
dc.contributor.authorPerez, Elizabeth Cristinapt_BR
dc.contributor.authorLallo, Maria Anetept_BR
dc.date.accessioned2020-07-09T21:19:15Z-
dc.date.available2020-07-09T21:19:15Z-
dc.date.issued2018-
dc.identifier.citationSantos DL, Alvares-Saraiva AM, Xavier JG, Spadacci-Morena DD, Peres GB, Rocha PRD'A, et al. B-1 cells upregulate CD8 T lymphocytes and increase proinflammatory cytokines serum levels in oral encephalitozoonosis. Microbes Infect. 2018 Mar;20(3):196-204. doi:10.1016/j.micinf.2017.11.004.pt_BR
dc.identifier.issn1286-4579-
dc.identifier.issn1769-714X-
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2407-
dc.description.abstractMicrosporidia are intracellular pathogens that cause severe disease in immunocompromised humans and animals. We recently demonstrated that XID mice are more susceptible to Encephalitozoon cuniculi infection by intraperitoneal route, evidencing the role of B-1 cells in resistance against infection. The present study investigated the resistance and susceptibility against E. cuniculi oral infection, including the role of B-1 cells. BALB/c and BALB/c XID (B-1 cells deficient) mice were orally infected with E. cuniculi spores. No clinical symptoms were observed in infected animals; histopathology showed lymphoplasmocytic enteritis with degeneration of the apexes of the villi in all infected groups. Higher parasite burden was observed in infected BALB/c XID mice. In the spleen and peritoneum, all infected mice showed a decrease of lymphocytes, including CD8(+) T cells, mostly in infected BALB/c XID mice. Adoptive transfer of B-1 cells (XID thorn B-1) was associated with a lower parasite burden. Pro-inflammatory cytokines (IFN-gamma, TNF-alpha and IL-6) increased mostly in infected XID + B1 mice. Together, the present results showed that BALB/c XID mice infected by the oral route were more susceptible to encephalitozoonosis than BALB/c mice, demonstrating the B-1 cells importance in the control of the immune response against oral E. cuniculi infection.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.format.extentp. 196-204pt_BR
dc.languageengpt_BR
dc.publisherElsevierpt_BR
dc.relation.ispartofMicrobes and Infectionpt_BR
dc.titleB-1 cells upregulate CD8 T lymphocytes and increase proinflammatory cytokines serum levels in oral encephalitozoonosispt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.micinf.2017.11.004pt_BR
dc.identifier.urlhttp://dx.doi.org/10.1016/j.micinf.2017.11.004pt_BR
dc.contributor.externalUniversidade Paulista (UNIP)¦¦Brasilpt_BR
dc.publisher.cityParispt_BR
dc.identifier.citationvolume20pt_BR
dc.identifier.citationissue3pt_BR
dc.subject.keywordB-1 cellspt_BR
dc.subject.keywordEncephalitozoonosispt_BR
dc.subject.keywordMicrosporidia infectionpt_BR
dc.subject.keywordInterferonpt_BR
dc.subject.keywordXID micept_BR
dc.relation.ispartofabbreviatedMicrobes Infectpt_BR
dc.identifier.citationabntv. 20, n. 3, p. 196-204, mar. 2018pt_BR
dc.identifier.citationvancouver2018 Mar;20(3):196-204pt_BR
dc.publisher.countryFrancept_BR
dc.contributor.butantanSpadacci-Morena, Diva Denelle|:Pesquisador|:Laboratório de Fisiopatologia|:pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2012/51-727-5pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
item.openairetypeArticle-
item.fulltextSem Texto completo-
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