Impaired expression of CXCL5 and matrix metalloproteinases in the lungs of mice with high susceptibility to Streptococcus pneumoniae infection

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dc.contributorLaboratório de Bacteriologiapt_BR
dc.contributorLaboratório de Imunoquímicapt_BR
dc.contributor.authorMancuso, Rubia Islerpt_BR
dc.contributor.authorMiyaji, Eliane Namiept_BR
dc.contributor.authorSilva, Cristiane Castilho Fernandes dapt_BR
dc.contributor.authorPortaro, Fernanda Calheta Vieirapt_BR
dc.contributor.authorSchanoski, Alessandra Soarespt_BR
dc.contributor.authorRibeiro, Orlando Garciapt_BR
dc.contributor.authorOliveira, Maria Leonor Sarno dept_BR
dc.date.accessioned2020-07-09T21:19:17Z-
dc.date.available2020-07-09T21:19:17Z-
dc.date.issued2018-
dc.identifier.citationMancuso RI, Miyaji EN, Silva CCF, Portaro FCV, Schanoski AS, Ribeiro OG, et al. Impaired expression of CXCL5 and matrix metalloproteinases in the lungs of mice with high susceptibility to Streptococcus pneumoniae infection. Immun Inflamm Dis. 2018 Mar;6(1):128-42. doi:10.1002/iid3.205.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2410-
dc.description.abstractIntroduction: Streptococcus pneumoniae colonizes the nasopharynx of healthy individuals establishing a commensal relationship with the host. In some conditions, bacteria invade the lower respiratory tract and innate immune responses are crucial to avoid diseases such as pneumonia, sepsis, or meningitis. Methods: Here, we compared the susceptibility to pneumococcal respiratory infection of two outbred mouse lines, AIRmin and AIRmax, selected for low or high acute inflammatory responses, respectively. Results: AIRmin mice showed increased susceptibility to infection with different pneumococcal serotypes, when compared to AIRmax. Significant higher numbers of alveolar macrophages expressing the CD206 mannose receptor were observed in AIRmin mice when compared to AIRmax mice. Despite this difference, secretion of several cytokines and chemokines in the respiratory tract of AIRmin and AIRmax mice, after infection, was similar. The only exception was CXCL5, which was highly induced after pneumococcal infection in AIRmax mice but not in AIRmin mice. Reduced expression of the matrix metalloproteinases (MMP) 2, 3, 8, and 9, as well as reduced activities of MMPs were also observed in the lungs of AIRmin mice, after infection. Such impaired responses may have contributed to the low influx of neutrophils observed in the airways of these mice. Finally, high percentages of macrophages and neutrophils in apoptosis or necrosis, at the site of infection, were also observed in AIRmin mice, suggesting that leukocyte functionality is also compromised. Conclusions: Our results indicate that CXCL5 and MMPs contribute to the resistance to pneumococcal infection in mice.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extentp. 128-142pt_BR
dc.languageengpt_BR
dc.relation.ispartofImmunity, Inflammation and Diseasept_BR
dc.rightsOpen Accesspt_BR
dc.titleImpaired expression of CXCL5 and matrix metalloproteinases in the lungs of mice with high susceptibility to Streptococcus pneumoniae infectionpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1002/iid3.205pt_BR
dc.identifier.urlhttp://dx.doi.org/10.1002/iid3.205pt_BR
dc.identifier.citationvolume6pt_BR
dc.identifier.citationissue1pt_BR
dc.subject.keywordinflammationpt_BR
dc.subject.keywordinnate immunitypt_BR
dc.subject.keywordrespiratorypt_BR
dc.subject.keywordStreptococcus pneumoniaept_BR
dc.relation.ispartofabbreviatedImmun Inflamm Dispt_BR
dc.identifier.citationabntv. 6, n. 1, p. 128-142, mar. 2018pt_BR
dc.identifier.citationvancouver2018 Mar;6(1):128-42pt_BR
dc.contributor.butantanMiyaji, Eliane Namie|:Pesquisador|:Laboratório de Bacteriologia|:pt_BR
dc.contributor.butantanSilva, Cristiane Castilho Fernandes da|:Aluno|:Laboratório de Imunoquímica|:pt_BR
dc.contributor.butantanSchanoski, Alessandra Soares|:Pesquisador|:Laboratório de Bacteriologia|:Autor de correspondênciapt_BR
dc.contributor.butantanRibeiro, Orlando Garcia|:Pesquisador|:Laboratório de Imunoquímica|:pt_BR
dc.contributor.butantanOliveira, Maria Leonor Sarno de|:Pesquisador|:Laboratório de Bacteriologia|:Autor de correspondênciapt_BR
dc.contributor.butantanMancuso, Rubia Isler|:Aluno|:Laboratório de Bacteriologia|:PrimeiroAutorpt_BR
dc.contributor.butantanPortaro, Fernanda Calheta Vieira|:Pesquisador:Docente Permanente PPGTOX|:Laboratório de Imunoquímica|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦473847/2013-2pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/11087-2pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/15364-3pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/26052-7pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
item.openairetypeArticle-
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item.grantfulltextembargo_29990101-
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