A comparative study of pathophysiological alterations in scorpionism induced by Tityus serrulatus and Tityus bahiensis venoms

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dc.contributorLab. Artrópodespt_BR
dc.contributor.authorMiyamoto, Jackson G.pt_BR
dc.contributor.authorAndrade, Fabio B.pt_BR
dc.contributor.authorFerraz, Camila R.pt_BR
dc.contributor.authorCandido, Denise Mariapt_BR
dc.contributor.authorKnysak, Irenept_BR
dc.contributor.authorVenancio, Emerson J.pt_BR
dc.contributor.authorVerri, Waldiceu A., Jr.pt_BR
dc.contributor.authorLandgraf, Maristella A.pt_BR
dc.contributor.authorLandgraf, Richardt G.pt_BR
dc.contributor.authorKwasniewski, Fabio H.pt_BR
dc.date.accessioned2020-07-09T21:19:46Z-
dc.date.available2020-07-09T21:19:46Z-
dc.date.issued2018pt_BR
dc.identifier.citationMiyamoto JG., Andrade FB., Ferraz CR., Candido DM, Knysak I, Venancio EJ., et al. A comparative study of pathophysiological alterations in scorpionism induced by Tityus serrulatus and Tityus bahiensis venoms. Toxicon. 2018 Jan;141:25-33. doi:10.1016/j.toxicon.2017.11.005.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2445-
dc.description.abstractScorpionism is a relevant public health problem in several countries in tropical and subtropical regions. In Brazil, Tityus serrulatus sting can induce acute lung injury in part as a consequence of inflammation. Despite the occurrence of other scorpions of Tityus genus in Brazilian scorpiofauna, the knowledge regarding pulmonary alterations is related to T. serrulatus venom (Tsv). Here we studied, comparatively, the pathophysiological changes in the rat airways envenomed by Tsv or T. bahiensis venom (Tbv), since both scorpions are involved in human accidents but with severe envenomations occurring when victims are stung by T. serrulatus. After intravenous injection of the venoms (200 mu g/kg), both were able to induce Evans blue extravasation (in 30 min) into airways and increased protein extravasation into lungs at 4 and 24 h, but the magnitude of such events was higher in Tsv group. Hemorrhage (in 60 min) in the lungs was higher in Tbv group, while IL-1 beta (at 1 h) and IL-6 (at 1 and 4 h) in lung homogenates were detected only in Tsv group. Four and 24 h after envenomation, myeloperoxidase activity in lung was equally augmented in the envenomed groups, as well as an increased in polymorphonuclear cell numbers in bronchoalveolar lavage fluid. At 4 h blood leukogram showed increased leukocyte values with the highest neutrophilia in Tsv group. The numbers of leukocytes and neutrophils remained higher than control at 24 h in Tsv and Tbv groups, and it was accompanied by lympho (envenomed groups) and monocytosis (Tsv group). In conclusion, although Tbv was capable of inducing acute lung injury and blood leukocyte mobilization, most of the evaluated parameters were more affected by the Tsv. These results could help to explain the pathophysiology of the scorpionism and the clinical data arguing toward the greatest severity associated with T. serrulatus stings.pt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.extentp. 25-33pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxiconpt_BR
dc.rightsRestricted accesspt_BR
dc.titleA comparative study of pathophysiological alterations in scorpionism induced by Tityus serrulatus and Tityus bahiensis venomspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.toxicon.2017.11.005pt_BR
dc.identifier.urlhttp://dx.doi.org/10.1016/j.toxicon.2017.11.005pt_BR
dc.contributor.external(UEL) Universidade Estadual de Londrinapt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.external(UNIFESP) Universidade Federal de São Paulopt_BR
dc.identifier.citationvolume141pt_BR
dc.subject.keywordTityuspt_BR
dc.subject.keywordScorpion venomspt_BR
dc.subject.keywordAirwayspt_BR
dc.subject.keywordEdemapt_BR
dc.subject.keywordLeukocytespt_BR
dc.subject.keywordcytokinespt_BR
dc.relation.ispartofabbreviatedToxiconpt_BR
dc.identifier.citationabntv. 141, p. 25-33, jan. 2018pt_BR
dc.identifier.citationvancouver2018 Jan;141:25-33pt_BR
dc.contributor.butantanCandido, Denise Maria|:Técnico|:Lab. Artrópodes|:pt_BR
dc.contributor.butantanKnysak, Irene|:Colaborador|:Lab. Artrópodes|:pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦Universal 457512/2014-8pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2012/51104-8pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2017/02042-3pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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