Effects of mild running on substantia nigra during early neurodegeneration

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dc.contributorLab. Biofísicapt_BR
dc.contributor.authorAlmeida, Michael F.pt_BR
dc.contributor.authorSilva, Carolliny M.pt_BR
dc.contributor.authorChaves, Rodrigo S.pt_BR
dc.contributor.authorLima, Nathan C. R.pt_BR
dc.contributor.authorAlmeida, Renato S.pt_BR
dc.contributor.authorMelo, Karla P.pt_BR
dc.contributor.authorDemasi, Marilenept_BR
dc.contributor.authorFernandes, Tiagopt_BR
dc.contributor.authorOliveira, Edilamar M.pt_BR
dc.contributor.authorNetto, Luis E. S.pt_BR
dc.contributor.authorCardoso, Sandra M.pt_BR
dc.contributor.authorFerrari, Merari F. R.pt_BR
dc.date.accessioned2020-07-09T21:19:50Z-
dc.date.available2020-07-09T21:19:50Z-
dc.date.issued2018pt_BR
dc.identifier.citationAlmeida MF., Silva CM., Chaves RS., Lima NC.R., Almeida RS., Melo KP., et al. Effects of mild running on substantia nigra during early neurodegeneration. J. Sports Sci.. 2018;36(12):1363-70. doi:10.1080/02640414.2017.1378494.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2449-
dc.description.abstractModerate physical exercise acts at molecular and behavioural levels, such as interfering in neuroplasticity, cell death, neurogenesis, cognition and motor functions. Therefore, the aim of this study is to analyse the cellular effects of moderate treadmill running upon substantia nigra during early neurodegeneration. Aged male Lewis rats (9-month-old) were exposed to rotenone 1mg/kg/day (8weeks) and 6weeks of moderate treadmill running, beginning 4weeks after rotenone exposure. Substantia nigra was extracted and submitted to proteasome and antioxidant enzymes activities, hydrogen peroxide levels and Western blot to evaluate tyrosine hydroxylase (TH), alpha-synuclein, Tom-20, PINK1, TrkB, SLP1, CRMP-2, Rab-27b, LC3II and Beclin-1 level. It was demonstrated that moderate treadmill running, practiced during early neurodegeneration, prevented the increase of alpha-synuclein and maintained the levels of TH unaltered in substantia nigra of aged rats. Physical exercise also stimulated autophagy and prevented impairment of mitophagy, but decreased proteasome activity in rotenone-exposed aged rats. Physical activity also prevented H2O2 increase during early neurodegeneration, although the involved mechanism remains to be elucidated. TrkB levels and its anterograde trafficking seem not to be influenced by moderate treadmill running. In conclusion, moderate physical training could prevent early neurodegeneration in substantia nigra through the improvement of autophagy and mitophagy.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT)pt_BR
dc.format.extentp. 1363-1370pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofJournal of Sports Sciencespt_BR
dc.rightsOpen Accesspt_BR
dc.titleEffects of mild running on substantia nigra during early neurodegenerationpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1080/02640414.2017.1378494pt_BR
dc.identifier.urlhttp://dx.doi.org/10.1080/02640414.2017.1378494pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalUniversidade de Taubaté (UNITAU)¦¦Brasilpt_BR
dc.contributor.externalUniversidade de Coimbra¦¦Portugalpt_BR
dc.identifier.citationvolume36pt_BR
dc.identifier.citationissue12pt_BR
dc.subject.keywordMitophagypt_BR
dc.subject.keywordproteasome activitypt_BR
dc.subject.keywordoxidative stresspt_BR
dc.subject.keywordrotenonept_BR
dc.subject.keywordtreadmill runningpt_BR
dc.relation.ispartofabbreviatedJ Sports Scipt_BR
dc.identifier.citationabntv. 36, n. 12, p. 1363-1370, 2018pt_BR
dc.identifier.citationvancouver2018;36(12):1363-70pt_BR
dc.contributor.butantanDemasi, Marilene|:Pesquisador|:Lab. Biofísica|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦471999/2013-0pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦401670/2013-9pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2011/06434-7pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/08028-1pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/18961- 2pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2011/15281-0, 2011/15283-2pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2011/00478-2pt_BR
dc.sponsorship.butantanFundação para a Ciência e a Tecnologia (FCT)¦¦PEst-C/SAU/LA0001/2011-2013pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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