Pathology and pathogenesis of human leptospirosis: a commented review

Butantan affiliation
Publication type
Access rights
Open Access
Appears in Collections:
Leptospirosis is an acute bacterial septicemic febrile disease caused by pathogenic leptospires, which affect humans and animals in all parts of the world. Transmission can occur by direct contact with infected animals or, more commonly, through indirect contact with water or soil contaminated with urine from infected animals. Leptospires enter the body by penetrating mucous membranes or skin abrasions and disseminate through the hematogenic route. In humans, leptospirosis may cause a wide spectrum of symptoms. Most cases have a biphasic clinical presentation, which begins with the septicemic phase followed by immune manifestations. The severe forms of the disease may be life threatening with multisystem damage including renal failure, hepatic dysfunction, vascular damage, pulmonary hemorrhage and muscle lesions. In this review, we present and discuss the pathogenesis of the human disease and the mechanisms of cell membrane injuries, which occur mainly due to the presence of leptospires and/or their antigen/s in the host tissues.
De Brito T, Gonçalves da Silva AM, Abreu PAE. Pathology and pathogenesis of human leptospirosis: a commented review. Rev. Inst. Med. Trop. Sao Paulo. 2018;60:e23. doi:10.1590/S1678-9946201860023.
Link to cite this reference
Issue Date

Files in This Item:

Size: 4.24 MB
Format: Adobe PDF
Show full item record

The access to the publications deposited in this repository respects the licenses from journals and publishers.