18F-Fluoride PET/CT and 99mTc-MDP SPECT/CT can detect bone cancer at early stage in rodents

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dc.contributorLEDS - Laboratório de Dor e Sinalizaçãopt_BR
dc.contributor.authorAlves, Christiano R. R.pt_BR
dc.contributor.authorFaria, Daniele de P.pt_BR
dc.contributor.authorCarneiro, Camila de G.pt_BR
dc.contributor.authorGarcez, Alexandre T.pt_BR
dc.contributor.authorGutierrez, Vanessa Pacciaript_BR
dc.contributor.authorNeves, Willian daspt_BR
dc.contributor.authorAlmeida, Ney R. dept_BR
dc.contributor.authorCury, Yarapt_BR
dc.contributor.authorChammas, Rogerpt_BR
dc.date.accessioned2020-07-09T21:20:11Z-
dc.date.available2020-07-09T21:20:11Z-
dc.date.issued2018pt_BR
dc.identifier.citationAlves CR.R., Faria DP., Carneiro CG., Garcez AT., Gutierrez VP, Neves W, et al. 18F-Fluoride PET/CT and 99mTc-MDP SPECT/CT can detect bone cancer at early stage in rodents. Life Sci.. 2018 Aug;206:29-34. doi:10.1016/j.lfs.2018.05.030.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2475-
dc.description.abstractNoninvasive imaging using positron emission tomography/computed tomography (PET/CT) and single photon emission computed tomography/computed tomography (SPECT/CT) are considered revolutionized approaches to detect bone cancer. Both PET/CT and SPECT/CT technologies have advanced to permit miniaturization, which has provided the advantage of including animals as their own controls in longitudinal studies. The present study was designed to evaluate the potential of PET/CT and SPECT/CT as research tools to detect bone cancer in rats. We used a rat model of bone cancer induced by injecting Walker 256 tumor cells into the femoral cavity. Computed tomography demonstrated that rats presented a solid tumor at 15 days post injection (dpi). However, CT was not an effective method for identifying tumors at an earlier time point (8 dpi), when mechanical hyperalgesia (the most common symptom during bone cancer progression) had already initiated. At this early stage, PET/CT and SPECT/CT analysis detected higher uptake in the injected femur of the tracers F-18-Fluoride and Tc-99m-Methyl diphosphonate (Tc-99m-MDP), respectively. These findings demonstrated for the first time that both F-18-Fluoride PET/CT and Tc-99m-MDP SPECT/CT can detect cancer at early stages in rats and advocates for the PET/SPECT/CT as research tools to evaluate bone cancer in further longitudinal studies involving small animals.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.format.extentp. 29-34pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofLife Sciencespt_BR
dc.title18F-Fluoride PET/CT and 99mTc-MDP SPECT/CT can detect bone cancer at early stage in rodentspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.lfs.2018.05.030pt_BR
dc.identifier.urlhttps://dx.doi.org/10.1016/j.lfs.2018.05.030pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalHarvard University¦¦Estados Unidospt_BR
dc.identifier.citationvolume206pt_BR
dc.subject.keywordImagingpt_BR
dc.subject.keywordOncologypt_BR
dc.subject.keywordCancer painpt_BR
dc.subject.keywordBone metabolismpt_BR
dc.subject.keywordSmall animal modelspt_BR
dc.relation.ispartofabbreviatedLife Scipt_BR
dc.identifier.citationabntv. 206, p. 29-34, ago. 2018pt_BR
dc.identifier.citationvancouver2018 Aug;206:29-34pt_BR
dc.contributor.butantanGutierrez, Vanessa Pacciari|:Aluno|:LEDS - Laboratório de Dor e Sinalização|:pt_BR
dc.contributor.butantanCury, Yara|:Pesquisador|:LEDS - Laboratório de Dor e Sinalização|:pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦16/01478-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦14/03016-8pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦12/25240-1pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦12/02528-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦15/22814-5pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
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item.grantfulltextembargo_29990101-
item.languageiso639-1English-
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