The primary duct of Bothrops jararaca glandular apparatus secretes toxins

Full metadata record
DC FieldValueLanguage
dc.contributorLaboratório de Farmacologiapt_BR
dc.contributorLaboratório de Imunopatologiapt_BR
dc.contributorLaboratório de Biologia Celularpt_BR
dc.contributor.authorValente, Richard Hemmipt_BR
dc.contributor.authorSakai, Fernandapt_BR
dc.contributor.authorPortes Júnior, José Antoniopt_BR
dc.contributor.authorViana, Luciana Godoypt_BR
dc.contributor.authorCarneiro, Sylvia Mendespt_BR
dc.contributor.authorPerales, Jonas Enrique Aguilarpt_BR
dc.contributor.authorYamanouye, Normapt_BR
dc.date.accessioned2020-07-09T21:20:13Z-
dc.date.available2020-07-09T21:20:13Z-
dc.date.issued2018-
dc.identifier.citationValente RH, Sakai F, Portes Júnior JA, Viana LG, Carneiro SM, Perales JEA, et al. The primary duct of Bothrops jararaca glandular apparatus secretes toxins. Toxins. 2018 Mar;10(3):121. doi:10.3390/toxins10030121.pt_BR
dc.identifier.issn2072-6651-
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2479-
dc.description.abstractDespite numerous studies concerning morphology and venom production and secretion in the main venom gland (and some data on the accessory gland) of the venom glandular apparatus of Viperidae snakes, the primary duct has been overlooked. We characterized the primary duct of the Bothrops jararaca snake by morphological analysis, immunohistochemistry and proteomics. The duct has a pseudostratified epithelium with secretory columnar cells with vesicles of various electrondensities, as well as mitochondria-rich, dark, basal, and horizontal cells. Morphological analysis, at different periods after venom extraction, showed that the primary duct has a long cycle of synthesis and secretion, as do the main venom and accessory glands; however, the duct has a mixed mode venom storage, both in the lumen and in secretory vesicles. Mouse anti-B. jararaca venom serum strongly stained the primary duct's epithelium. Subsequent proteomic analysis revealed the synthesis of venom toxins-mainly C-type lectin/C-type lectin-like proteins. We propose that the primary duct's toxin synthesis products complement the final venom bolus. Finally, we hypothesize that the primary duct and the accessory gland (components of the venom glandular apparatus) are part of the evolutionary path from a salivary gland towards the main venom gland.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)pt_BR
dc.format.extent121pt_BR
dc.languageengpt_BR
dc.publisherMDPI AGpt_BR
dc.relation.ispartofToxinspt_BR
dc.titleThe primary duct of Bothrops jararaca glandular apparatus secretes toxinspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/toxins10030121pt_BR
dc.identifier.urlhttp://dx.doi.org/10.3390/toxins10030121pt_BR
dc.contributor.externalFundação Oswaldo Cruz (Fiocruz)¦¦Brasilpt_BR
dc.contributor.externalInstituto Nacional de Ciência e Tecnologia em Toxinas (INCTTOX)¦¦Brasilpt_BR
dc.publisher.cityBaselpt_BR
dc.identifier.citationvolume10pt_BR
dc.identifier.citationissue3pt_BR
dc.subject.keywordvenom glandular apparatuspt_BR
dc.subject.keywordprimary ductpt_BR
dc.subject.keywordmorphologypt_BR
dc.subject.keywordsecretory cyclept_BR
dc.subject.keywordvenom productionpt_BR
dc.subject.keywordproteomicspt_BR
dc.subject.keywordBothrops jararacapt_BR
dc.relation.ispartofabbreviatedToxinspt_BR
dc.identifier.citationabntv. 10, n. 3, 121, mar. 2018pt_BR
dc.identifier.citationvancouver2018 Mar;10(3):121pt_BR
dc.publisher.countrySwitzerlandpt_BR
dc.contributor.butantanSakai, Fernanda|:Aluno|:Laboratório de Farmacologia|:pt_BR
dc.contributor.butantanPortes Júnior, José Antonio|:Aluno|:Laboratório de Imunopatologia|:pt_BR
dc.contributor.butantanViana, Luciana Godoy|:Aluno|:Laboratório de Farmacologia|:pt_BR
dc.contributor.butantanCarneiro, Sylvia Mendes|:Pesquisador|:Laboratório de Biologia Celular|:pt_BR
dc.contributor.butantanYamanouye, Norma|:Pesquisador|:Laboratório de Farmacologia|:Autor de correspondênciapt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦312311/2013-3pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦AuxPE 1214/2011pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦AuxPE 1224/2011pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2007/50083-9pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/21221-5pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)¦¦E26/202-960/2015pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.openairetypeArticle-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journalissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journaleissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
Appears in Collections:Artigos de periódicos


Files in This Item:

10.3390toxins10030121.pdf
Size: 6.02 MB
Format: Adobe PDF
View/Open
Show simple item record

The access to the publications deposited in this repository respects the licenses from journals and publishers.