Development of vaccines against Zika virus

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dc.contributorCentro de Ensaios Clínicos e Farmacovigilânciapt_BR
dc.contributorCentro Bioindustrialpt_BR
dc.contributor.authorPoland, Gregory A.pt_BR
dc.contributor.authorKennedy, Richard B.pt_BR
dc.contributor.authorOvsyannikova, Inna G.pt_BR
dc.contributor.authorPalacios, Ricardopt_BR
dc.contributor.authorHo, Paulo Leept_BR
dc.contributor.authorKalil, Jorgept_BR
dc.identifier.citationPoland GA., Kennedy RB., Ovsyannikova IG., Palacios R, Ho PL, Kalil J. Development of vaccines against Zika virus. Lancet Infect. Dis.. 2018 Jul;18(7):e211-9. doi:10.1016/S1473-3099(18)30063-X.pt_BR
dc.description.abstractZika virus is an emerging pathogen of substantial public health concern to human beings. Although most infections are asymptomatic or present with benign, self-limited symptoms, a small percentage of patients have complications, such as congenital anomalies in the developing fetus of pregnant women infected with the virus and neurological complications (eg, Guillain-Barre syndrome). To date, there is no vaccine, antiviral drug, or other modality available to prevent or treat Zika virus infection. In this Review, we examine vaccine development efforts for Zika virus to date and research gaps in the development of candidate vaccines against Zika virus. Top research priorities should include development of a better understanding of immunity to Zika virus to establish clear correlates of protection; determination of what effect, if any, Zika vaccine-induced immune responses will have on subsequent dengue virus infection; evaluation of vaccine immunogenicity and efficacy in healthy adults and in the various subpopulations affected by Zika virus infection (children, pregnant women, women of childbearing age, and eldery people); and identification of the molecular mechanisms that underlie birth defects and neurological sequelae related to Zika virus.pt_BR
dc.format.extentp. e211-e219pt_BR
dc.relation.ispartofThe Lancet Infectious Diseasespt_BR
dc.titleDevelopment of vaccines against Zika viruspt_BR
dc.contributor.externalMayo Clinic¦¦Estados Unidospt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.relation.ispartofabbreviatedLancet Infect Dispt_BR
dc.identifier.citationabntv. 18, n. 7, p. e211-e219, jul. 2018pt_BR
dc.identifier.citationvancouver2018 Jul;18(7):e211-9pt_BR
dc.contributor.butantanPalacios, Ricardo|:Pesquisador|:Centro de Ensaios Clínicos e Farmacovigilância|:pt_BR
dc.contributor.butantanHo, Paulo Lee|:Pesquisador|:Centro Bioindustrial|:pt_BR
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