The holo-transcriptome of the zoantharian Protopalythoa variabilis (Cnidaria: Anthozoa): a plentiful source of enzymes for potential application in green chemistry, industrial and pharmaceutical biotechnology

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dc.contributor(LG) Laboratório de Genéticapt_BR
dc.contributor.authorMorlighem, Jean-Etienne R. L.pt_BR
dc.contributor.authorHuang, Chenpt_BR
dc.contributor.authorLiao, Qiwenpt_BR
dc.contributor.authorGomes, Paula Bragapt_BR
dc.contributor.authorPerez, Carlos Danielpt_BR
dc.contributor.authorPrieto da Silva, Álvaro Rossan de Brandãopt_BR
dc.contributor.authorLee, Simon Ming-Yuenpt_BR
dc.contributor.authorRadis-Baptista, Gandhipt_BR
dc.date.accessioned2020-07-09T21:20:33Z-
dc.date.available2020-07-09T21:20:33Z-
dc.date.issued2018pt_BR
dc.identifier.citationMorlighem J-ER.L., Huang C, Liao Q, Gomes PB, Perez CD, Prieto da Silva ARB, et al. The holo-transcriptome of the zoantharian Protopalythoa variabilis (Cnidaria: Anthozoa): a plentiful source of enzymes for potential application in green chemistry, industrial and pharmaceutical biotechnology. Mar. Drugs. 2018 Jun;16(6):207. doi:10.3390/md16060207.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2501-
dc.description.abstractMarine invertebrates, such as sponges, tunicates and cnidarians (zoantharians and scleractinian corals), form functional assemblages, known as holobionts, with numerous microbes. This type of species-specific symbiotic association can be a repository of myriad valuable low molecular weight organic compounds, bioactive peptides and enzymes. The zoantharian Protopalythoa variabilis (Cnidaria: Anthozoa) is one such example of a marine holobiont that inhabits the coastal reefs of the tropical Atlantic coast and is an interesting source of secondary metabolites and biologically active polypeptides. In the present study, we analyzed the entire holo-transcriptome of P. variabilis, looking for enzyme precursors expressed in the zoantharian-microbiota assemblage that are potentially useful as industrial biocatalysts and biopharmaceuticals. In addition to hundreds of predicted enzymes that fit into the classes of hydrolases, oxidoreductases and transferases that were found, novel enzyme precursors with multiple activities in single structures and enzymes with incomplete Enzyme Commission numbers were revealed. Our results indicated the predictive expression of thirteen multifunctional enzymes and 694 enzyme sequences with partially characterized activities, distributed in 23 sub-subclasses. These predicted enzyme structures and activities can prospectively be harnessed for applications in diverse areas of industrial and pharmaceutical biotechnology.pt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship(FDCT) Fundo de Desenvolvimento das Ciências e da Tecnologiapt_BR
dc.format.extent207pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofMarine Drugspt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleThe holo-transcriptome of the zoantharian Protopalythoa variabilis (Cnidaria: Anthozoa): a plentiful source of enzymes for potential application in green chemistry, industrial and pharmaceutical biotechnologypt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3390/md16060207pt_BR
dc.identifier.urlhttp://dx.doi.org/10.3390/md16060207pt_BR
dc.contributor.external(UFC) Universidade Federal do Cearápt_BR
dc.contributor.externalUniversity of Macau (UM)pt_BR
dc.contributor.external(UFRPE) Universidade Federal Rural de Pernambucopt_BR
dc.contributor.external(UFPE) Universidade Federal de Pernambucopt_BR
dc.identifier.citationvolume16pt_BR
dc.identifier.citationissue6pt_BR
dc.subject.keywordZoanthideapt_BR
dc.subject.keywordholo-transcriptomept_BR
dc.subject.keywordcnidarian transcriptomept_BR
dc.subject.keywordmarine enzymept_BR
dc.subject.keywordmarine biocatalystpt_BR
dc.subject.keywordmarine biotechnologypt_BR
dc.subject.keywordpharmaceutical biotechnologypt_BR
dc.relation.ispartofabbreviatedMar Drugspt_BR
dc.identifier.citationabntv. 16, n. 6, 207, jun. 2018pt_BR
dc.identifier.citationvancouver2018 Jun;16(6):207pt_BR
dc.contributor.butantanPrieto da Silva, Álvaro Rossan de Brandão|:Pesquisador|:Lab. Genética|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦408835/2013-3pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦408934/2013-1pt_BR
dc.sponsorship.butantanFundo de Desenvolvimento das Ciências e da Tecnologia (FDCT)¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
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item.languageiso639-1English-
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