Hydroquinone exposure worsens the symptomatology of rheumatoid arthritis


Butantan affiliation
Publication type
Article
Language
English
Appears in Collections:
Metrics
Abstract
The genesis of rheumatoid arthritis (RA) is complex and dependent on genetic background and exposure to environmental xenobiotic. Indeed, smoking is associated to developing and worsening pre-existing RA. Nevertheless, the mechanisms and cigarette compounds involved in the harmful processes have not been elucidated. Here, we investigated if the exposure to hydroquinone (HQ), an abundant pro-oxidative compound of cigarette and benzene metabolite, could worsen the ongoing RA. Hence, collagen-induced arthritis (CIA) was induced in male Wistar rats by s.c. injection of 400 lig (200 mu L) of bovine collagen type II emulsified in complete Freund's adjuvant on day 1, and a booster injection was performed on day 7. Exposures to nebulized HQ (25 ppm), saline solution or HQ vehicle solution (5% ethanol in saline) were carried out for 1 h, once a day, on days 21-27 after CIA induction. On day 27, animals were euthanized and samples were collected for further analyses. Exposure to HQ caused loss of weight, intensified paw edema, enhanced levels of tumor necrosis factor-alpha (TNF-alpha) and anti-citrullinated protein antibody (ACPA) in the serum; augmented synoviocyte proliferation and influx of aril hydrocarbon receptor (AhR) positive cells into the synovial membrane, altered collagen fibre rearrangement in the synovia, and synoviocytes isolated from HQ exposed rats secreted higher levels of proinflammatory cytokines, TNF-alpha and interleukin-15. Associated, we point out HQ as an environmental pollutant that aggravates RA, suggesting its participation on worsening RA in smoking patients.
Reference
Heluany CS, Kanda Kupa LV, Viana MN, Fernandes CM, Poliselli Farsky SH. Hydroquinone exposure worsens the symptomatology of rheumatoid arthritis. Chem.-Biol. Interact.. 2018 Aug;291:120-7. doi:10.1016/j.cbi.2018.06.016.
Link to cite this reference
https://repositorio.butantan.gov.br/handle/butantan/2522
Issue Date
2018


Files in This Item:

Existing users please Login
10.1016j.cbi.2018.06.016.pdf
Size: 1.97 MB
Format: Adobe PDF
Embargoed until January 1, 2999    Request a copy
Show full item record

The access to the publications deposited in this repository respects the licenses from journals and publishers.