Potamotrygon motoro stingray venom induces both neurogenic and inflammatory pain behavior in rodents

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dc.contributor(LEDS) Laboratório de Dor e Sinalizaçãopt_BR
dc.contributorLab. Imunopatologiapt_BR
dc.contributor.authorKimura, Louise Faggionatopt_BR
dc.contributor.authorSantos-Neto, Miguel Oliveirapt_BR
dc.contributor.authorBarbaro, Katia Cristinapt_BR
dc.contributor.authorPicolo, Giselept_BR
dc.date.accessioned2020-07-09T21:20:51Z-
dc.date.available2020-07-09T21:20:51Z-
dc.date.issued2018pt_BR
dc.identifier.citationKimura LF, Santos-Neto MO, Barbaro KC, Picolo G. Potamotrygon motoro stingray venom induces both neurogenic and inflammatory pain behavior in rodents. Toxicon. 2018 Aug;150:168-74. doi:10.1016/j.toxicon.2018.05.018.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2525-
dc.description.abstractFreshwater stingray accidents cause an immediate, intense, and unrelieved pain which is followed by edema, erythema and necrosis formation. Treatment for stingray envenomation is based on administration of analgesic, antipyretic and anti-inflammatory drugs. Concerning pain control, it is prescribed to immerse punctured limb on hot water to alleviate pain. There are no studies demonstrating specific targets on which stingray venom acts to promote pain. Therefore, the aim of this work was to investigate some mechanisms of Potamotrygon motoro venom (PmV) that contribute to nociception induction. Evaluating spontaneous pain behavior in mice injected i.pl. with PmV, it was seen that PmV induced both neurogenic and inflammatory pain. PmV also induced hyperalgesia in both mice and rats, evaluated through electronic von Frey and rat paw pressure test, respectively. Partial inhibition of hyperalgesia was observed in mice treated with cromolyn or promethazine, which indicated that mast cell and histamine via H1 receptor participate in the inflammatory pain. To search for some targets involved in PmVinduced hyperalgesia, the participation of TRPV1, calcium channels, neurokinins, CGRP, and norepinephrine, was evaluated in rats. It was seen that PmV-induced hyperalgesia occurs with the participation of neurokinins, mainly via NK1 receptor, CGRP, and calcium influx, through both P/Q and L-type voltage-dependent calcium channels, besides TRPV1 activation. The data presented herein indicate that PmV causes hyperalgesia in rodents which is dependent on the participation of several neuroinflammatory mediators.pt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.extentp. 168-174pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxiconpt_BR
dc.titlePotamotrygon motoro stingray venom induces both neurogenic and inflammatory pain behavior in rodentspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.toxicon.2018.05.018pt_BR
dc.identifier.urlhttp://dx.doi.org/10.1016/j.toxicon.2018.05.018pt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.identifier.citationvolume150pt_BR
dc.subject.keywordInflammatory painpt_BR
dc.subject.keywordNeurogenic painpt_BR
dc.subject.keywordPain mediatorspt_BR
dc.subject.keywordPotamotrygon motoropt_BR
dc.subject.keywordStingray venompt_BR
dc.relation.ispartofabbreviatedToxiconpt_BR
dc.identifier.citationabntv. 150, p. 168-174, ago. 2018pt_BR
dc.identifier.citationvancouver2018 Aug;150:168-74pt_BR
dc.contributor.butantanSantos-Neto, Miguel Oliveira|:Aluno|:Lab. Imunopatologia|:pt_BR
dc.contributor.butantanBarbaro, Katia Cristina|:Pesquisador|:Lab. Imunopatologia|:pt_BR
dc.contributor.butantanKimura, Louise Faggionato|:Aluno|:Laboratório de Dor e Sinalização|:PrimeiroAutorpt_BR
dc.contributor.butantanPicolo, Gisele|:Pesquisador:Docente Permanente PPGTOX|:Laboratório de Dor e Sinalização|:Autor de correspondênciapt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦573790/2008-6pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2012/00166-3pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2008/57898-0pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2007/55272-4pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.grantfulltextembargo_29990101-
item.languageiso639-1English-
item.fulltextCom Texto completo-
item.openairetypeArticle-
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