The potential of Loxosceles gaucho spider venom to regulate Pseudomonas aeruginosa mechanisms of virulence

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dc.contributorLab. Bacteriologiapt_BR
dc.contributorLab. Bioquímicapt_BR
dc.contributorLab. Imunopatologiapt_BR
dc.contributor.authorDomingos, Marta de Oliveirapt_BR
dc.contributor.authorNeves, Irys Vianapt_BR
dc.contributor.authorVigerelli, Hugopt_BR
dc.contributor.authorPimenta, Daniel Carvalhopt_BR
dc.contributor.authorTávora, Bianca de Carvalho Lins Fernandespt_BR
dc.contributor.authorLemos, Thiago Jordão da Silvapt_BR
dc.contributor.authorFranzolin, Marcia Reginapt_BR
dc.contributor.authorMarques, Vaniky Duartept_BR
dc.contributor.authorBarbaro, Katia Cristinapt_BR
dc.date.accessioned2020-07-09T21:21:08Z-
dc.date.available2020-07-09T21:21:08Z-
dc.date.issued2018pt_BR
dc.identifier.citationDomingos MO, Neves IV, Vigerelli H, Pimenta DC, Távora BCLF, Lemos TJS, et al. The potential of Loxosceles gaucho spider venom to regulate Pseudomonas aeruginosa mechanisms of virulence. Toxicon. 2018 Sep;152:78-83. doi:10.1016/j.toxicon.2018.07.017.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2548-
dc.description.abstractLoxosceles venom is a potential source of bioactive molecules which may be transformed into antimicrobial products against multi-resistant bacteria. Here, it was investigated whether Loxosceles gaucho spider had any influence on the proliferation, enzyme release and biofilm formation of a Pseudomonas aeruginosa strain resistant to two different classes of antibiotic. The results demonstrated that L. gaucho whole venom has no influence on P. aeruginosa proliferation. However, it increases P. aeruginosa production of gelatinase, caseinase and biofilm formation. The same effects were noted when P. aeruginosa was exposed to a L. gaucho venom molecular fraction with mass lower than 1 kDa. Separation of this molecular fraction into different subsets by RP-HPLC demonstrated that, among the molecules with the ability to increase the production of enzymes and biofilm formation, there are some with antimicrobial activities whose effects are not observed in the whole venom. In summary, the results obtained herein indicate that L. gaucho venom has a variety of low molecular mass bioactive components that influence the mechanisms of virulence of P. aeruginosa in different ways.pt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(FINEP) Financiadora de Estudos e Projetospt_BR
dc.format.extentp. 78-83pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxiconpt_BR
dc.titleThe potential of Loxosceles gaucho spider venom to regulate Pseudomonas aeruginosa mechanisms of virulencept_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.toxicon.2018.07.017pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.toxicon.2018.07.017pt_BR
dc.identifier.citationvolume152pt_BR
dc.subject.keywordLoxosceles gauchopt_BR
dc.subject.keywordPseudomonas aeruginosapt_BR
dc.subject.keywordbiofilmpt_BR
dc.subject.keywordBacterial proliferationpt_BR
dc.subject.keywordCaseinasept_BR
dc.subject.keywordGelatinasept_BR
dc.relation.ispartofabbreviatedToxiconpt_BR
dc.identifier.citationabntv. 152, p. 78-83, set. 2018pt_BR
dc.identifier.citationvancouver2018 Sep;152:78-83pt_BR
dc.contributor.butantanNeves, Irys Viana|:Aluno|:Lab. Bacteriologia|:pt_BR
dc.contributor.butantanTávora, Bianca de Carvalho Lins Fernandes|:Técnico|:Lab. Imunopatologia|:pt_BR
dc.contributor.butantanLemos, Thiago Jordão da Silva|:Aluno|:Lab. Bacteriologia|:pt_BR
dc.contributor.butantanFranzolin, Marcia Regina|:Pesquisador|:Lab. Bacteriologia|:pt_BR
dc.contributor.butantanMarques, Vaniky Duarte|:Aluno|:Lab. Bacteriologia|:pt_BR
dc.contributor.butantanBarbaro, Katia Cristina|:Pesquisador|:Lab. Imunopatologia|:pt_BR
dc.contributor.butantanDomingos, Marta de Oliveira|:Pesquisador|:Lab. Bacteriologia|:PrimeiroAutor:Autor de correspondênciapt_BR
dc.contributor.butantanVigerelli, Hugo|:Aluno:Docente Colaborador PPGTOX|:Lab. Bioquímica|:pt_BR
dc.contributor.butantanPimenta, Daniel Carvalho|:Pesquisador:Docente Permanente PPGTOX|:Lab. Bioquímica|:pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦303792/2016-7pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦pt_BR
dc.sponsorship.butantanFinanciadora de Estudos e Projetos (FINEP)¦¦01.12.0450.03pt_BR
dc.sponsorship.butantanFinanciadora de Estudos e Projetos (FINEP)¦¦01.09.0278.04pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.grantfulltextembargo_29990101-
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