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The physiological role of the free 20S proteasome in protein degradation: a critical review

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Campo DCValoridioma
dc.contributorLab. Bioquímicapt_BR
dc.contributor.authorDemasi, Marilenept_BR
dc.contributor.authorCunha, Fernanda Marques dapt_BR
dc.date.accessioned2020-07-09T21:21:36Z-
dc.date.available2020-07-09T21:21:36Z-
dc.date.issued2018pt_BR
dc.identifier.citationDemasi M, Cunha FM. The physiological role of the free 20S proteasome in protein degradation: a critical review. Biochim. Biophys. Acta Gen. Subj.. 2018 Dec;1862(12):2948-54. doi:10.1016/j.bbagen.2018.09.009.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2582-
dc.description.abstractBackground It has been almost three decades since the removal of oxidized proteins by the free 20S catalytic unit of the proteasome (20SPT) was proposed. Since then, experimental evidence suggesting a physiological role of proteolysis mediated by the free 20SPT has being gathered. Scope of review Experimental data that favors the hypothesis of free 20SPT as playing a role in proteolysis are critically reviewed. Major conclusions Protein degradation by the proteasome may proceed through multiple proteasome complexes with different requirements though the unequivocal role of the free 20SPT in cellular proteolysis towards native or oxidized proteins remains to be demonstrated. General significance The biological significance of proteolysis mediated by the free 20SPT has been elusive since its discovery. The present review critically analyzes the available experimental data supporting the proteolytic role of the free or single capped 20SPT.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.extentp. 2948-2954pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofBiochimica et Biophysica Acta. General Subjectspt_BR
dc.rightsRestricted accesspt_BR
dc.titleThe physiological role of the free 20S proteasome in protein degradation: a critical reviewpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.bbagen.2018.09.009pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.bbagen.2018.09.009pt_BR
dc.contributor.external(UNIFESP) Universidade Federal de São Paulopt_BR
dc.identifier.citationvolume1862pt_BR
dc.identifier.citationissue12pt_BR
dc.subject.keywordUbiquitin-proteasome systempt_BR
dc.subject.keywordProteasomal complexespt_BR
dc.subject.keywordUbiquitin- and ATP-independent protein degradationpt_BR
dc.relation.ispartofabbreviatedBiochim Biophys Acta Gen Subjpt_BR
dc.identifier.citationabntv. 1862, n. 12, p. 2948-2954, dez. 2018pt_BR
dc.identifier.citationvancouver2018 Dec;1862(12):2948-54pt_BR
dc.contributor.butantanDemasi, Marilene|:Pesquisador|:Lab. Bioquímica|:PrimeiroAutorpt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/07937-8pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.fulltextSem Texto completo-
item.languageiso639-1English-
item.openairetypeArticle-
item.grantfulltextnone-
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