Effectiveness of Lonomia antivenom in recovery from the coagulopathy induced by Lonomia orientoandensis and Lonomia casanarensis caterpillars in rats

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dc.contributorLab. Fisiopatologiapt_BR
dc.contributor.authorSano-Martins, Ida Siguekopt_BR
dc.contributor.authorGonzález, Camilapt_BR
dc.contributor.authorAnjos, Isabelle Valle dospt_BR
dc.contributor.authorDiaz, Juanapt_BR
dc.contributor.authorGonçalves, Luis Roberto de Camargopt_BR
dc.date.accessioned2020-07-09T21:21:45Z-
dc.date.available2020-07-09T21:21:45Z-
dc.date.issued2018pt_BR
dc.identifier.citationSano-Martins IS, González C, Anjos IV, Diaz J, Gonçalves LRC. Effectiveness of Lonomia antivenom in recovery from the coagulopathy induced by Lonomia orientoandensis and Lonomia casanarensis caterpillars in rats. Plos Neglect. Trop. Dis.. 2018 Ago;12(8):e0006721. doi:10.1371/journal.pntd.0006721.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2592-
dc.description.abstractIn South America, accidental contact with Lepidoptera larvae can produce a diversity of reactions that vary from dermatological problems to severe hemorrhagic syndromes, such as those caused by contact with caterpillars of the genus Lonomia (Saturniidae). Lonomia venom can alter the hemostatic system and lead to renal failure, internal and brain bleeding, and in severe cases, death. The only specific treatment available for these envenomations is the Lonomia Antivenom (LAV) produced by the Butantan Institute, in Brazil, using an extract of Lonomia obliqua scoli as the antigen. LAV has been used to treat exposure to other Lonomia species across South America. However, no experimental studies have been performed to test the efficacy of LAV in neutralizing the venom of species other than L. obliqua found in Southern Brazil. In this study, we tested the effectiveness of LAV in reversing the hemostatic disturbances induced by injecting Lonomia casanarensis (Lca) and Lonomia orientoandensis (Lor) scolus extracts into rats and compared the effects to the case of L. obliqua (Lob) scolus extract-induced envenomation. Lca and Lor caterpillars were collected in Colombia, and some of them were reared to adults for identification. The Minimum Defibrinating Doses (MDD) of Lca and Lor were estimated. Rats were injected (i.d.) with a dose of 3 MDD per rat of each scolus extract and treated (i.v.) with 1.5 mL of LAV or 1.5 mL of saline. Twenty-four hours after the treatment, the fibrinogen levels and platelet counts had recovered to the hemostatic levels in the groups treated with LAV. The groups treated with the saline solution had fibrinogen levels and platelet counts at non-hemostatic levels. Thromboelastometric analyses confirmed these results. In conclusion, the results showed that LAV is effective at neutralizing the envenomation induced by Lca and Lor spine extracts in rats and restoring hemostasis.pt_BR
dc.description.sponsorshipUniversidad del Cauca (UNICAUCA)pt_BR
dc.format.extente0006721pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofPlos Neglected Tropical Diseasespt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleEffectiveness of Lonomia antivenom in recovery from the coagulopathy induced by Lonomia orientoandensis and Lonomia casanarensis caterpillars in ratspt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.1371/journal.pntd.0006721pt_BR
dc.identifier.urlhttps://doi.org/10.1371/journal.pntd.0006721pt_BR
dc.contributor.externalUniversidad de los Andes¦¦Colômbiapt_BR
dc.identifier.citationvolume12pt_BR
dc.identifier.citationissue8pt_BR
dc.relation.ispartofabbreviatedPlos Neglect Trop Dispt_BR
dc.identifier.citationabntv. 12, n. 8, e0006721, ago. 2018pt_BR
dc.identifier.citationvancouver2018 Ago;12(8):e0006721pt_BR
dc.contributor.butantanAnjos, Isabelle Valle dos|:Aluno|:Lab. Fisiopatologia|:pt_BR
dc.contributor.butantanSano-Martins, Ida Sigueko|:Pesquisador|:Lab. Fisiopatologia|:PrimeiroAutor:Autor de correspondênciapt_BR
dc.contributor.butantanGonçalves, Luis Roberto de Camargo|:Pesquisador:Docente Colaborador PPGTOX|:Lab. Fisiopatologia|:pt_BR
dc.sponsorship.butantan(UNICAUCA) Universidad del Cauca||pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1English-
item.openairetypeArticle-
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