Crotoxin-treated macrophages stimulate ROS production and killing activity in co-cultured neutrophils

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dc.contributorLab. Fisiopatologiapt_BR
dc.contributor.authorde Oliveira, Renata Begliomini Brunopt_BR
dc.contributor.authorKato, Ellen Emipt_BR
dc.contributor.authorCirillo, Maria Cristinapt_BR
dc.contributor.authorLima, Tatiane Soarespt_BR
dc.contributor.authorAlba-Loureiro, Tatiana Carolinapt_BR
dc.contributor.authorCuri, Ruipt_BR
dc.contributor.authorSampaio, Sandra Coccuzzopt_BR
dc.date.accessioned2020-07-09T21:21:55Z-
dc.date.available2020-07-09T21:21:55Z-
dc.date.issued2018pt_BR
dc.identifier.citationde Oliveira RBB, Kato EE, Cirillo MC, Lima TS, Alba-Loureiro TC, Curi R, et al. Crotoxin-treated macrophages stimulate ROS production and killing activity in co-cultured neutrophils. J. Appl. Microb. Res.. 2018;1(1):55-65pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2604-
dc.description.abstractCrotoxin (CTX), the predominant toxin in Crotalus durissus terrificus snake venom (CdtV), has anti-inflammatory and immunomodulatory effects. Despite its inhibitory action on neutrophil migration and phagocytosis, CTX does not directly affect the production of reactive oxygen species (ROS) by the neutrophils. In contrast, it enhances the generation of reactive oxygen and nitrogen intermediates by macrophages. Given the importance of macrophage-neutrophil interactions in innate antimicrobial defense, the aim of this study was to investigate the effect of CTX on neutrophil ROS production and killing activity, either through CTX-treated macrophage co-culture or conditioned medium of CTX-treated macrophages. The results showed an important modulatory action of CTX on the neutrophil function as well as neutrophil-macrophage interactions, as demonstrated by the increased production of hydrogen peroxide, hypochlorous acid, nitric oxide and TNF- a , along with the increased fungicidal activity of neutrophils.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.format.extentp. 55-65pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofJournal of Applied Microbiological Researchpt_BR
dc.rightsOpen Accesspt_BR
dc.titleCrotoxin-treated macrophages stimulate ROS production and killing activity in co-cultured neutrophilspt_BR
dc.typeArticlept_BR
dc.identifier.urlhttp://innovationinfo.org/journal-of-applied-microbiological-research/article/Crotoxin-Treated-Macrophages-Stimulate-ROS-Production-and-Killing-Activity-in-co-cultured-Neutrophils#pdfpt_BR
dc.contributor.externalUniversity of California Irvinepolpt_BR
dc.contributor.externalUniversidade de São Paulo (USP)pt_BR
dc.contributor.externalUniversidade Cruzeiro do Sul (UNICSUL)pt_BR
dc.identifier.citationvolume1pt_BR
dc.identifier.citationissue1pt_BR
dc.subject.keywordCrotoxinpt_BR
dc.subject.keywordMacrophagespt_BR
dc.subject.keywordNeutrophilspt_BR
dc.subject.keywordInflammationpt_BR
dc.subject.keywordATPpt_BR
dc.subject.keywordReactive oxygen and nitrogen speciespt_BR
dc.subject.keywordCytokinespt_BR
dc.subject.keywordCo-culture modelpt_BR
dc.relation.ispartofabbreviatedJ Appl Microb Respt_BR
dc.identifier.citationabntv. 1, n. 1, p. 55-65, 2018pt_BR
dc.identifier.citationvancouver2018;1(1):55-65pt_BR
dc.contributor.butantanKato, Ellen Emi|:Aluno PPGTOX|:Lab. Fisiopatologia|:pt_BR
dc.contributor.butantanCirillo, Maria Cristina|:Pesquisador|:Lab. Fisiopatologia|:pt_BR
dc.contributor.butantanLima, Tatiane Soares|:Aluno|:Lab. Fisiopatologia|:pt_BR
dc.contributor.butantande Oliveira, Renata Begliomini Bruno|:Aluno|:Lab. Fisiopatologia|:PrimeiroAutorpt_BR
dc.contributor.butantanSampaio, Sandra Coccuzzo|:Pesquisador:Docente Permanente PPGTOX|:Lab. Fisiopatologia|:Autor de correspondênciapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2009/52330-9pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2012/08880-7pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedNopt_BR
item.openairetypeArticle-
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item.grantfulltextopen-
item.languageiso639-1English-
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