Understanding toxicological implications of accidents with caterpillars Megalopyge lanata and Podalia orsilochus (Lepidoptera: Megalopygidae)

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dc.contributorLaboratório de Artrópodespt_BR
dc.contributor.authorSánchez, Matías Nicoláspt_BR
dc.contributor.authorSciani, Juliana Mozerpt_BR
dc.contributor.authorQuintana, María Agustinapt_BR
dc.contributor.authorMartínez, María Mercedespt_BR
dc.contributor.authorTavares, Flávio Luizpt_BR
dc.contributor.authorGritti, Micaela A.pt_BR
dc.contributor.authorFan, Hui Wenpt_BR
dc.contributor.authorTeibler, Gladys Pamelapt_BR
dc.contributor.authorPeichoto, María Elisapt_BR
dc.date.accessioned2020-07-09T21:22:14Z-
dc.date.available2020-07-09T21:22:14Z-
dc.date.issued2019-
dc.identifier.citationSánchez MN, Sciani JM, Quintana MA, Martínez MM, Tavares FL, Gritti MA., et al. Understanding toxicological implications of accidents with caterpillars Megalopyge lanata and Podalia orsilochus (Lepidoptera: Megalopygidae). Comp. Biochem. Physiol. C Toxicol. Pharmacol.. 2019 Feb;216:110-119. doi:10.1016/j.cbpc.2018.11.011.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2623-
dc.description.abstractMegalopygids Megalopyge lanata and Podalia orsilochus are common causative agents of accidents in agricultural workers. These accidents are provoked by dermal contact at their larval stage and are characterized by cutaneous reactions, such as burning pain, edema and erythema, typically mild and self-limited. There is very little information about their venoms and their toxicological implications on human health. Thus, we employed proteomic techniques and biological assays to characterize venoms (bristle extracts) from caterpillars of both species collected from Misiones, Argentina. The electrophoretic profiles of both venoms were substantially different, and they presented proteins related to toxicity, such as serinepeptidases, serpins and lectins. P. orsilochus venom exhibited higher caseinolytic activity than M. lanata venom, agreeing with the fact that only P. orsilochus venom hydrolyzed human fibrin(ogen). In addition, the latter shortened the clotting time triggered by calcium. While the venom of M. lanata induced a mild inflammatory lesion in mouse skin, P. orsilochus venom caused prominent necrosis, inflammatory infiltration and hemorrhage at the site of venom injection. On the other hand, P. orsilochus venom was better recognized by Lonomia obliqua antivenom, although many of its proteins could not be cross-reacted, what may explain the difference in the clinical manifestations between accidents by Podalia and those by Lonomia. Altogether, this study provides relevant information about the pathophysiological mechanisms whereby both caterpillars can induce toxicity on human beings, and paves the way for novel discovery of naturally occurring bioactive compounds.pt_BR
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT)pt_BR
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET)pt_BR
dc.format.extentp. 110-119pt_BR
dc.languageengpt_BR
dc.relation.ispartofComparative Biochemistry and Physiology Part C: Toxicology & Pharmacologypt_BR
dc.titleUnderstanding toxicological implications of accidents with caterpillars Megalopyge lanata and Podalia orsilochus (Lepidoptera: Megalopygidae)pt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.cbpc.2018.11.011pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.cbpc.2018.11.011pt_BR
dc.contributor.externalConsejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)¦¦Argentinapt_BR
dc.contributor.externalInstituto Nacional de Medicina Tropical (INMeT)¦¦Argentinapt_BR
dc.contributor.externalUniversidad Nacional del Nordeste (UNNE)¦¦Argentinapt_BR
dc.contributor.externalUniversidade São Francisco (USF)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal da Integração Latino-Americana (UNILA)¦¦Brasilpt_BR
dc.identifier.citationvolume216pt_BR
dc.subject.keywordCutaneous lesionpt_BR
dc.subject.keywordEnzymept_BR
dc.subject.keywordLepidopteran larvapt_BR
dc.subject.keywordMass spectrometrypt_BR
dc.subject.keywordBristlept_BR
dc.subject.keywordVenompt_BR
dc.relation.ispartofabbreviatedComp. Biochem. Physiol. C Toxicol. Pharmacol.pt_BR
dc.identifier.citationabntv. 216, p. 110-119, fev. 2019pt_BR
dc.identifier.citationvancouver2019 Feb;216:110-119pt_BR
dc.contributor.butantanFan, Hui Wen|:Pesquisador|:Laboratório de Artrópodes|:pt_BR
dc.sponsorship.butantanAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT)¦¦PICT-2013-1238pt_BR
dc.sponsorship.butantanConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET)¦¦PIP 112-201301-00126-COpt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
item.fulltextCom Texto completo-
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