Hepatoprotective properties from the seaweed Bryothamnion triquetrum (S.G.Gmelin) M.A.Howe against CCl4-induced oxidative damage in rats

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dc.contributorLab. Virologiapt_BR
dc.contributor.authorVidal Novoa, Alexis de J.pt_BR
dc.contributor.authorSilva, Ana M. de Oliveira ept_BR
dc.contributor.authorMancini, Dalva Assunção Portaript_BR
dc.contributor.authorDíaz Gutiérrez, Daylínpt_BR
dc.contributor.authorMancini-Filho, Jorgept_BR
dc.date.accessioned2020-07-09T21:22:33Z-
dc.date.available2020-07-09T21:22:33Z-
dc.date.issued2019pt_BR
dc.identifier.citationVidal Novoa AJ., Silva AM.O, Mancini DAP, Díaz Gutiérrez D, Mancini-Filho J. Hepatoprotective properties from the seaweed Bryothamnion triquetrum (S.G.Gmelin) M.A.Howe against CCl4-induced oxidative damage in rats. J Pharm Pharmacogn Res. 2019 Jan;7(1):31-46. doi:https://repositorio.butantan.gov.br/handle/butantan/2648.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2648-
dc.description.abstractContext: Seaweeds are seen as a traditional food and folk medicine by different coastal countries. The red seaweed Bryothamnion triquetrum is a widely distributed species that grows in shallow waters, and different authors have demonstrated a possible application of the seaweeds as a source of natural antioxidants and relative diseases. Aims: To evaluate the hepatoprotective properties on CCl4-induced oxidative stress in rats that were associated with the antioxidant activity from the polyphenol-rich fractions of the red seaweed Bryothamnion triquetrum. Methods: Polyphenols were determined by Folin-Cioacalteu. Antioxidant activity from phenolic compounds-rich fractions was measured by different assays (DPPH, Reducing power, (beta-Carotene/linoleic acid assay and Inhibition of lipoperoxidation). Aqueous extract from B. triquetrum was administered during 20 days to rats and submitted CCl4-Induced oxidative damage. The peroxidation and hepatic damage (TBARS, ASAT and ALAT), antioxidant metabolite and enzymes (glutathione, catalase and superoxide dismutase) were evaluated. Also, it was evaluated the expression of antioxidant enzymes by RT-PCR. Results: The antioxidant activity determined by different assays with polyphenolic fractions. Free Phenolic Acid was more active: DPPH, 20 mu g 87%; Reducing power OD = 0.490, 20 g; beta-carotene/linoleic acid 1 mu g 53%, and inhibition of lipid peroxidation 0.250 mu g 100%. Rats treated displayed lower liver TBARS, ASAT and ALAT than CCl4-treated group and catalase activity was increased. It was demonstrated expression of catalase. Conclusions: Data suggest that Bryothamnion triquetrum protects the liver against oxidative stress by modulating its antioxidant enzymes and oxidative status with potential use as phytodrug or functional food.pt_BR
dc.format.extentp. 31-46pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofJournal of Pharmacy & Pharmacognosy Researchpt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/pt_BR
dc.titleHepatoprotective properties from the seaweed Bryothamnion triquetrum (S.G.Gmelin) M.A.Howe against CCl4-induced oxidative damage in ratspt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BY-NC-NDpt_BR
dc.identifier.urlhttp://jppres.com/jppres/pdf/vol7/jppres18.419_7.1.31.pdfpt_BR
dc.contributor.externalUniversidad de la Habana¦¦Cubapt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.identifier.citationvolume7pt_BR
dc.identifier.citationissue1pt_BR
dc.subject.keywordantioxidantpt_BR
dc.subject.keywordBryothamnion triquetumpt_BR
dc.subject.keywordhepatoprotectionpt_BR
dc.subject.keywordseaweedspt_BR
dc.relation.ispartofabbreviatedJ Pharm Pharmacogn Respt_BR
dc.identifier.citationabntv. 7, n. 1, p. 31-46, jan. 2019pt_BR
dc.identifier.citationvancouver2019 Jan;7(1):31-46pt_BR
dc.contributor.butantanMancini, Dalva Assunção Portari|:Colaborador|:Lab. Virologia|:pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
item.fulltextCom Texto completo-
item.openairetypeArticle-
item.grantfulltextopen-
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