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Mild exercise differently affects proteostasis and oxidative stress on motor areas during neurodegeneration: a comparative study of three treadmill running protocols
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DC Field | Value | Language |
---|---|---|
dc.contributor | Lab. Bioquímica | pt_BR |
dc.contributor.author | Melo, Karla P. | pt_BR |
dc.contributor.author | Silva, Carolliny M. | pt_BR |
dc.contributor.author | Almeida, Michael F. | pt_BR |
dc.contributor.author | Chaves, Rodrigo S. | pt_BR |
dc.contributor.author | Marcourakis, Tania | pt_BR |
dc.contributor.author | Cardoso, Sandra M. | pt_BR |
dc.contributor.author | Demasi, Marilene | pt_BR |
dc.contributor.author | Netto, Luis E. S. | pt_BR |
dc.contributor.author | Ferrari, Merari F. R. | pt_BR |
dc.date.accessioned | 2020-07-09T21:22:38Z | - |
dc.date.available | 2020-07-09T21:22:38Z | - |
dc.date.issued | 2019 | pt_BR |
dc.identifier.citation | Melo KP., Silva CM., Almeida MF., Chaves RS., Marcourakis T, Cardoso SM., et al. Mild exercise differently affects proteostasis and oxidative stress on motor areas during neurodegeneration: a comparative study of three treadmill running protocols. Neurotox. Res.. 2019 Feb;35(2):410-420. doi:10.1007/s12640-018-9966-3. | pt_BR |
dc.identifier.uri | https://repositorio.butantan.gov.br/handle/butantan/2654 | - |
dc.description.abstract | Proteostasis and oxidative stress were evaluated in motor cortex and spinal cord of aged Lewis rats exposed to 1mg/kg/day of rotenone during 4 or 8weeks, prior or after practicing three protocols of mild treadmill running. Results demonstrated that exercise done after the beginning of neurodegeneration reverted the increased oxidative stress (measured by H2O2 levels and SOD activity), increased neuron strength, and improved proteostasis in motor cortex. Spinal cord was not affected. Treadmill running practiced before neurodegeneration protected cortical motor neurons of the rotenone-exposed rats; but in this case, oxidative stress was not altered, whereas proteasome activity was increased and autophagy decreased. Spinal cord was not protected when exercise was practiced before neurodegeneration. Prolonged treadmill running (10weeks) increased oxidative stress, autophagy, and proteasome activity, whereas neuron viability was decreased in motor cortex. In spinal cord, this protocol decreased oxidative stress and increased proteasome activity. Major conclusions were that treadmill running practiced before or after the beginning of neurodegeneration may protect motor cortex neurons, whereas prolonged mild running seems to be beneficial for spinal cord. | pt_BR |
dc.description.sponsorship | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo | pt_BR |
dc.description.sponsorship | (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico | pt_BR |
dc.description.sponsorship | (CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior | pt_BR |
dc.format.extent | p. 410-420 | pt_BR |
dc.language.iso | English | pt_BR |
dc.relation.ispartof | Neurotoxicity Research | pt_BR |
dc.rights | Restricted access | pt_BR |
dc.title | Mild exercise differently affects proteostasis and oxidative stress on motor areas during neurodegeneration: a comparative study of three treadmill running protocols | pt_BR |
dc.type | Article | pt_BR |
dc.identifier.doi | 10.1007/s12640-018-9966-3 | pt_BR |
dc.identifier.url | http://dx.doi.org/10.1007/s12640-018-9966-3 | pt_BR |
dc.contributor.external | (USP) Universidade de São Paulo | pt_BR |
dc.contributor.external | Universidade de Coimbra | pt_BR |
dc.identifier.citationvolume | 35 | pt_BR |
dc.identifier.citationissue | 2 | pt_BR |
dc.subject.keyword | Spinal cord | pt_BR |
dc.subject.keyword | Motor cortex | pt_BR |
dc.subject.keyword | Autophagy | pt_BR |
dc.subject.keyword | Rotenone | pt_BR |
dc.subject.keyword | Physical exercise | pt_BR |
dc.subject.keyword | Proteasome | pt_BR |
dc.relation.ispartofabbreviated | Neurotox Res | pt_BR |
dc.identifier.citationabnt | v. 35, n. 2, p. 410-420, fev. 2019 | pt_BR |
dc.identifier.citationvancouver | 2019 Feb;35(2):410-420 | pt_BR |
dc.contributor.butantan | Demasi, Marilene|:Pesquisador|:Lab. Bioquímica|: | pt_BR |
dc.sponsorship.butantan | (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦471999/2013-0 | pt_BR |
dc.sponsorship.butantan | (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦401670/2013-9 | pt_BR |
dc.sponsorship.butantan | (CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦ | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2011/06434-7 | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2013/08028-1 | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2015/18961-2 | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2011/15281-0 | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2011/15283-2 | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2011/00478-2 | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2017/14273-0 | pt_BR |
dc.identifier.bvscc | BR78.1 | pt_BR |
dc.identifier.bvsdb | IBProd | pt_BR |
dc.description.dbindexed | Yes | pt_BR |
item.fulltext | Sem Texto completo | - |
item.languageiso639-1 | English | - |
item.openairetype | Article | - |
item.grantfulltext | none | - |
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