Mild exercise differently affects proteostasis and oxidative stress on motor areas during neurodegeneration: a comparative study of three treadmill running protocols

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dc.contributorLab. Biofísicapt_BR
dc.contributor.authorMelo, Karla P.pt_BR
dc.contributor.authorSilva, Carolliny M.pt_BR
dc.contributor.authorAlmeida, Michael F.pt_BR
dc.contributor.authorChaves, Rodrigo S.pt_BR
dc.contributor.authorMarcourakis, Taniapt_BR
dc.contributor.authorCardoso, Sandra M.pt_BR
dc.contributor.authorDemasi, Marilenept_BR
dc.contributor.authorNetto, Luis E. S.pt_BR
dc.contributor.authorFerrari, Merari F. R.pt_BR
dc.date.accessioned2020-07-09T21:22:38Z-
dc.date.available2020-07-09T21:22:38Z-
dc.date.issued2019pt_BR
dc.identifier.citationMelo KP., Silva CM., Almeida MF., Chaves RS., Marcourakis T, Cardoso SM., et al. Mild exercise differently affects proteostasis and oxidative stress on motor areas during neurodegeneration: a comparative study of three treadmill running protocols. Neurotox. Res.. 2019 Feb;35(2):410-420. doi:10.1007/s12640-018-9966-3.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2654-
dc.description.abstractProteostasis and oxidative stress were evaluated in motor cortex and spinal cord of aged Lewis rats exposed to 1mg/kg/day of rotenone during 4 or 8weeks, prior or after practicing three protocols of mild treadmill running. Results demonstrated that exercise done after the beginning of neurodegeneration reverted the increased oxidative stress (measured by H2O2 levels and SOD activity), increased neuron strength, and improved proteostasis in motor cortex. Spinal cord was not affected. Treadmill running practiced before neurodegeneration protected cortical motor neurons of the rotenone-exposed rats; but in this case, oxidative stress was not altered, whereas proteasome activity was increased and autophagy decreased. Spinal cord was not protected when exercise was practiced before neurodegeneration. Prolonged treadmill running (10weeks) increased oxidative stress, autophagy, and proteasome activity, whereas neuron viability was decreased in motor cortex. In spinal cord, this protocol decreased oxidative stress and increased proteasome activity. Major conclusions were that treadmill running practiced before or after the beginning of neurodegeneration may protect motor cortex neurons, whereas prolonged mild running seems to be beneficial for spinal cord.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.format.extentp. 410-420pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofNeurotoxicity Researchpt_BR
dc.titleMild exercise differently affects proteostasis and oxidative stress on motor areas during neurodegeneration: a comparative study of three treadmill running protocolspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1007/s12640-018-9966-3pt_BR
dc.identifier.urlhttp://dx.doi.org/10.1007/s12640-018-9966-3pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalUniversidade de Coimbra¦¦Portugalpt_BR
dc.identifier.citationvolume35pt_BR
dc.identifier.citationissue2pt_BR
dc.subject.keywordSpinal cordpt_BR
dc.subject.keywordMotor cortexpt_BR
dc.subject.keywordAutophagypt_BR
dc.subject.keywordRotenonept_BR
dc.subject.keywordPhysical exercisept_BR
dc.subject.keywordProteasomept_BR
dc.relation.ispartofabbreviatedNeurotox Respt_BR
dc.identifier.citationabntv. 35, n. 2, p. 410-420, fev. 2019pt_BR
dc.identifier.citationvancouver2019 Feb;35(2):410-420pt_BR
dc.contributor.butantanDemasi, Marilene|:Pesquisador|:Lab. Biofísica|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦471999/2013-0pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦401670/2013-9pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2011/06434-7pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/08028-1pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/18961-2pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2011/15281-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2011/15283-2pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2011/00478-2pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/14273-0pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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