In silico analysis of genetic VapC profiles from the toxin-antitoxin type II VapBC modules among pathogenic, intermediate, and non-pathogenic Leptospira
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Laboratório Especial de Desenvolvimento de Vacinas (LEDV) | pt_BR |
dc.contributor.author | Lopes, Alexandre Paulo Yague | pt_BR |
dc.contributor.author | Azevedo, Bruna Oliveira Pigatto | pt_BR |
dc.contributor.author | Emídio, Rebeca Cordellini | pt_BR |
dc.contributor.author | Damiano, Deborah Kohn | pt_BR |
dc.contributor.author | Nascimento, Ana Lúcia Tabet Oller do | pt_BR |
dc.contributor.author | Barazzone, Giovana Cappio | pt_BR |
dc.date.accessioned | 2020-07-09T21:22:55Z | - |
dc.date.available | 2020-07-09T21:22:55Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Lopes APY, Azevedo BOP, Emídio RC, Damiano DK, Nascimento ALTO, Barazzone GC. In silico analysis of genetic VapC profiles from the toxin-antitoxin type II VapBC modules among pathogenic, intermediate, and non-pathogenic Leptospira. Microorganisms. 2019 Feb;7(2):56. doi:10.3390/microorganisms7020056. | pt_BR |
dc.identifier.uri | https://repositorio.butantan.gov.br/handle/butantan/2674 | - |
dc.description.abstract | Pathogenic Leptospira spp. is the etiological agent of leptospirosis. The high diversity among Leptospira species provides an array to look for important mediators involved in pathogenesis. Toxin-antitoxin (TA) systems represent an important survival mechanism on stress conditions. vapBC modules have been found in nearly one thousand genomes corresponding to about 40% of known TAs. In the present study, we investigated TA profiles of some strains of Leptospira using a TA database and compared them through protein alignment of VapC toxin sequences among Leptospira spp. genomes. Our analysis identified significant differences in the number of putative vapBC modules distributed in pathogenic, saprophytic, and intermediate strains: four in L. interrogans, three in L. borgpetersenii, eight in L. biflexa, and 15 in L. licerasiae. The VapC toxins show low identity among amino acid sequences within the species. Some VapC toxins appear to be exclusively conserved in unique species, others appear to be conserved among pathogenic or saprophytic strains, and some appear to be distributed randomly. The data shown here indicate that these modules evolved in a very complex manner, which highlights the strong need to identify and characterize new TAs as well as to understand their regulation networks and the possible roles of TA systems in pathogenic bacteria. | pt_BR |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | pt_BR |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | pt_BR |
dc.description.sponsorship | Fundação Butantan | pt_BR |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | pt_BR |
dc.format.extent | 56 | pt_BR |
dc.language | eng | pt_BR |
dc.relation.ispartof | Microorganisms | pt_BR |
dc.rights | Open Access | pt_BR |
dc.title | In silico analysis of genetic VapC profiles from the toxin-antitoxin type II VapBC modules among pathogenic, intermediate, and non-pathogenic Leptospira | pt_BR |
dc.type | Article | pt_BR |
dc.identifier.doi | 10.3390/microorganisms7020056 | pt_BR |
dc.identifier.url | https://doi.org/10.3390/microorganisms7020056 | pt_BR |
dc.contributor.external | Universidade de São Paulo (USP)¦¦Brasil | pt_BR |
dc.identifier.citationvolume | 7 | pt_BR |
dc.identifier.citationissue | 2 | pt_BR |
dc.subject.keyword | Toxin-antitoxin | pt_BR |
dc.subject.keyword | VapBC | pt_BR |
dc.subject.keyword | VapC | pt_BR |
dc.subject.keyword | Leptospira | pt_BR |
dc.relation.ispartofabbreviated | Microorganisms | pt_BR |
dc.identifier.citationabnt | v. 7, n. 2, 56, fev. 2019 | pt_BR |
dc.identifier.citationvancouver | 2019 Feb;7(2):56 | pt_BR |
dc.contributor.butantan | Lopes, Alexandre Paulo Yague|:Pesquisador|:Laboratório Especial de Desenvolvimento de Vacinas (LEDV)|:PrimeiroAutor:Autor de correspondência | pt_BR |
dc.contributor.butantan | Azevedo, Bruna Oliveira Pigatto|:Aluno|:Laboratório Especial de Desenvolvimento de Vacinas (LEDV)|: | pt_BR |
dc.contributor.butantan | Emídio, Rebeca Cordellini|:Aluno|:Laboratório Especial de Desenvolvimento de Vacinas (LEDV)|: | pt_BR |
dc.contributor.butantan | Damiano, Deborah Kohn|:Aluno|:Laboratório Especial de Desenvolvimento de Vacinas (LEDV)|: | pt_BR |
dc.contributor.butantan | Nascimento, Ana Lúcia Tabet Oller do|:Pesquisador|:Laboratório Especial de Desenvolvimento de Vacinas (LEDV)|: | pt_BR |
dc.contributor.butantan | Barazzone, Giovana Cappio|:Pesquisador|:Laboratório Especial de Desenvolvimento de Vacinas (LEDV)|: | pt_BR |
dc.sponsorship.butantan | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦301229/2017-1 | pt_BR |
dc.sponsorship.butantan | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦001 | pt_BR |
dc.sponsorship.butantan | Fundação Butantan¦¦ | pt_BR |
dc.sponsorship.butantan | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦14/50981-0 | pt_BR |
dc.identifier.bvscc | BR78.1 | pt_BR |
dc.identifier.bvsdb | IBProd | pt_BR |
item.openairetype | Article | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | embargo_29990101 | - |
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