In silico analysis of genetic VapC profiles from the toxin-antitoxin type II VapBC modules among pathogenic, intermediate, and non-pathogenic Leptospira

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dc.contributorLaboratório de Desenvolvimento de Vacinaspt_BR
dc.contributor.authorLopes, Alexandre Paulo Yaguept_BR
dc.contributor.authorAzevedo, Bruna Oliveira Pigattopt_BR
dc.contributor.authorEmídio, Rebeca Cordellinipt_BR
dc.contributor.authorDamiano, Deborah Kohnpt_BR
dc.contributor.authorNascimento, Ana Lúcia Tabet Oller dopt_BR
dc.contributor.authorBarazzone, Giovana Cappiopt_BR
dc.date.accessioned2020-07-09T21:22:55Z-
dc.date.available2020-07-09T21:22:55Z-
dc.date.issued2019pt_BR
dc.identifier.citationLopes APY, Azevedo BOP, Emídio RC, Damiano DK, Nascimento ALTO, Barazzone GC. In silico analysis of genetic VapC profiles from the toxin-antitoxin type II VapBC modules among pathogenic, intermediate, and non-pathogenic Leptospira. Microorganisms. 2019 Feb;7(2):56. doi:10.3390/microorganisms7020056.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2674-
dc.description.abstractPathogenic Leptospira spp. is the etiological agent of leptospirosis. The high diversity among Leptospira species provides an array to look for important mediators involved in pathogenesis. Toxin-antitoxin (TA) systems represent an important survival mechanism on stress conditions. vapBC modules have been found in nearly one thousand genomes corresponding to about 40% of known TAs. In the present study, we investigated TA profiles of some strains of Leptospira using a TA database and compared them through protein alignment of VapC toxin sequences among Leptospira spp. genomes. Our analysis identified significant differences in the number of putative vapBC modules distributed in pathogenic, saprophytic, and intermediate strains: four in L. interrogans, three in L. borgpetersenii, eight in L. biflexa, and 15 in L. licerasiae. The VapC toxins show low identity among amino acid sequences within the species. Some VapC toxins appear to be exclusively conserved in unique species, others appear to be conserved among pathogenic or saprophytic strains, and some appear to be distributed randomly. The data shown here indicate that these modules evolved in a very complex manner, which highlights the strong need to identify and characterize new TAs as well as to understand their regulation networks and the possible roles of TA systems in pathogenic bacteria.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação Butantanpt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.format.extent56pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofMicroorganismspt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleIn silico analysis of genetic VapC profiles from the toxin-antitoxin type II VapBC modules among pathogenic, intermediate, and non-pathogenic Leptospirapt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3390/microorganisms7020056pt_BR
dc.identifier.urlhttps://doi.org/10.3390/microorganisms7020056pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.identifier.citationvolume7pt_BR
dc.identifier.citationissue2pt_BR
dc.subject.keywordToxin-antitoxinpt_BR
dc.subject.keywordVapBCpt_BR
dc.subject.keywordVapCpt_BR
dc.subject.keywordLeptospirapt_BR
dc.relation.ispartofabbreviatedMicroorganismspt_BR
dc.identifier.citationabntv. 7, n. 2, 56, fev. 2019pt_BR
dc.identifier.citationvancouver2019 Feb;7(2):56pt_BR
dc.contributor.butantanLopes, Alexandre Paulo Yague|:Pesquisador|:Laboratório de Desenvolvimento de Vacinas|:PrimeiroAutor:Autor de correspondênciapt_BR
dc.contributor.butantanAzevedo, Bruna Oliveira Pigatto|:Aluno|:Laboratório de Desenvolvimento de Vacinas|:pt_BR
dc.contributor.butantanEmídio, Rebeca Cordellini|:Aluno|:Laboratório de Desenvolvimento de Vacinas|:pt_BR
dc.contributor.butantanDamiano, Deborah Kohn|:Aluno|:Laboratório de Desenvolvimento de Vacinas|:pt_BR
dc.contributor.butantanNascimento, Ana Lúcia Tabet Oller do|:Pesquisador|:Laboratório de Desenvolvimento de Vacinas|:pt_BR
dc.contributor.butantanBarazzone, Giovana Cappio|:Pesquisador|:Laboratório de Desenvolvimento de Vacinas|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦301229/2017-1pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦001pt_BR
dc.sponsorship.butantanFundação Butantan¦¦pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦14/50981-0pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
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