Factors associated with systemic bleeding in Bothrops envenomation in a tertiary hospital in the Brazilian Amazon

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dc.contributorLab. Fisiopatologiapt_BR
dc.contributor.authorOliveira, Sâmella S.pt_BR
dc.contributor.authorAlves, Eliane C.pt_BR
dc.contributor.authorSantos, Alessandra S.pt_BR
dc.contributor.authorPereira, João Pedro T.pt_BR
dc.contributor.authorSarraff, Lybia Kássia S.pt_BR
dc.contributor.authorNascimento, Elizandra F.pt_BR
dc.contributor.authorBrito-Sousa, José Diego dept_BR
dc.contributor.authorSampaio, Vanderson S.pt_BR
dc.contributor.authorLacerda, Marcus V.G.pt_BR
dc.contributor.authorSachett, Jacqueline A.G.pt_BR
dc.contributor.authorSano-Martins, Ida Siguekopt_BR
dc.contributor.authorMonteiro, Wuelton M.pt_BR
dc.date.accessioned2020-07-09T21:23:05Z-
dc.date.available2020-07-09T21:23:05Z-
dc.date.issued2019pt_BR
dc.identifier.citationOliveira SS., Alves EC., Santos AS., Pereira JPT., Sarraff LKS., Nascimento EF., et al. Factors associated with systemic bleeding in Bothrops envenomation in a tertiary hospital in the Brazilian Amazon. Toxins. 2019 Jan;11(1):22. doi:10.3390/toxins11010022.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2684-
dc.description.abstractBothrops snakebites usually present systemic bleeding, and the clinical–epidemiological and laboratorial factors associated with the development of this manifestation are not well established. In this study, we assessed the prevalence of Bothrops snakebites with systemic bleeding reported at the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, in Manaus, Amazonas State, Brazil, and the clinical–epidemiological and laboratorial factors associated with systemic bleeding. This is an observational, cross-sectional study carried out between August, 2013 and July, 2016. Patients who developed systemic bleeding on admission or during hospitalization were considered cases, and those with non-systemic bleeding were included in the control group. Systemic bleeding was observed in 63 (15.3%) of the 442 Bothrops snakebites evaluated. Bothrops snakebites mostly occurred in males (78.2%), in rural areas (89.0%) and in the age group of 11 to 30 years old (40.4%). It took most of the patients (59.8%) less than 3 h to receive medical assistance. Unclottable blood (AOR = 3.11 (95% CI = 1.53 to 6.31; p = 0.002)) and thrombocytopenia (AOR = 4.52 (95% CI = 2.03 to 10.09; p < 0.001)) on admission were independently associated with systemic bleeding during hospitalization. These hemostatic disorders on admission increase the chances of systemic bleeding during hospitalization. Prospective studies are needed to clarify the pathophysiology of systemic bleeding in Bothrops snakebites in the Amazon region.pt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.extent22pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxinspt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleFactors associated with systemic bleeding in Bothrops envenomation in a tertiary hospital in the Brazilian Amazonpt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3390/toxins11010022pt_BR
dc.identifier.urlhttp://dx.doi.org/10.3390/toxins11010022pt_BR
dc.contributor.externalUniversidade do Estado do Amazonas (UEA)¦¦Brasilpt_BR
dc.contributor.externalFundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD)¦¦Brasilpt_BR
dc.identifier.citationvolume11pt_BR
dc.identifier.citationissue1pt_BR
dc.subject.keywordhemostatic disorderspt_BR
dc.subject.keywordunclottable bloodpt_BR
dc.subject.keywordthrombocytopeniapt_BR
dc.subject.keywordBothrops atroxpt_BR
dc.relation.ispartofabbreviatedToxinspt_BR
dc.identifier.citationabntv. 11, n. 1, 22, jan. 2019pt_BR
dc.identifier.citationvancouver2019 Jan;11(1):22pt_BR
dc.contributor.butantanSano-Martins, Ida Sigueko|:Pesquisador|:Lab. Fisiopatologia|:pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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