Histopathological findings in the viscera of malformed neotropical viperids

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dc.contributorLaboratório de Herpetologiapt_BR
dc.contributor.authorCarvalho, M. P. N.pt_BR
dc.contributor.authorSant'Anna, Sávio Stefaninipt_BR
dc.contributor.authorDíaz-Delgado, J.pt_BR
dc.contributor.authorGrego, Kathleen Fernandespt_BR
dc.contributor.authorGogone, I. C. V. P.pt_BR
dc.contributor.authorQueiroz-Hazarbassanov, N. G. T.pt_BR
dc.contributor.authorCatão-Dias, J. L.pt_BR
dc.date.accessioned2020-07-09T21:23:29Z-
dc.date.available2020-07-09T21:23:29Z-
dc.date.issued2019-
dc.identifier.citationCarvalho M.P.N., Sant'Anna SS, Díaz-Delgado J., Grego KF, Gogone I.C.V.P., Queiroz-Hazarbassanov N.G.T., et al. Histopathological findings in the viscera of malformed neotropical viperids. J Comp Pathol. 2019 Feb;167:73-81. doi:10.1016/j.jcpa.2018.10.174.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2712-
dc.description.abstractCongenital malformations (CMs) or developmental abnormalities are pathological processes defined as morphological defects that originate during embryonic stages. A wide variety of CMs is observed in reptiles, most of which are incompatible with normal life. Characterization of CMs and their pathogenesis are of great importance for the conservation of reptiles, including neotropical viperids (NVs). External CMs are often reported in these species, but little is known about concomitant microscopical findings in the viscera of malformed individuals. In order to partially fill in this gap in knowledge, we aimed to investigate and characterize histopathological findings in the viscera of malformed NVs, jararacas (Bothrops jararaca) and South American rattlesnakes (Crotalus durissus), correlating these findings with features of external CMs. From 78 malformed snakes analysed, 100% (19/19) of rattlesnakes and 98.3% (58/59) of jararacas had histopathological changes in the viscera. Liver and/or kidney fatty degeneration was the most common finding in malformed and control animals. Renal glomerulocystic and tubular disease was significantly correlated with brachygnathia (P < 0.05) in jararacas. These results add to the body of knowledge of snake pathology and demonstrate some associations between external CMs and visceral histopathological findings, some of which could have implications for individual survival.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.format.extentp. 73-81pt_BR
dc.languageengpt_BR
dc.relation.ispartofJournal of Comparative Pathologypt_BR
dc.titleHistopathological findings in the viscera of malformed neotropical viperidspt_BR
dc.typeArticlept_BR
dc.identifier.doihttps://repositorio.butantan.gov.br/handle/butantan/2712pt_BR
dc.identifier.urlhttp://dx.doi.org/10.1016/j.jcpa.2018.10.174pt_BR
dc.contributor.externalUniversidade Federal de Minas Gerais (UFMG)¦¦Brasilpt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.identifier.citationvolume167pt_BR
dc.subject.keywordBothrops jararacapt_BR
dc.subject.keywordcongenital anomaliespt_BR
dc.subject.keywordCrotalus durissuspt_BR
dc.subject.keywordteratologypt_BR
dc.relation.ispartofabbreviatedJ Comp Patholpt_BR
dc.identifier.citationabntv. 73, p. 73-81, fev. 2019pt_BR
dc.identifier.citationvancouver2019 Feb;167:73-81pt_BR
dc.contributor.butantanSant'Anna, Sávio Stefanini|:Pesquisador|:Laboratório de Herpetologia|:pt_BR
dc.contributor.butantanGrego, Kathleen Fernandes|:Pesquisador|:Laboratório de Herpetologia|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦305349/2015-5pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/02223-8pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
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