Dynamics of encapsulated hepatitis B surface antigen: a combined neutron spectroscopy and thermo-analysis study

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dc.contributorLab. Virologiapt_BR
dc.contributorLab. Imunoquímicapt_BR
dc.contributor.authorRasmussen, Martin K.pt_BR
dc.contributor.authorPereira, José E. M.pt_BR
dc.contributor.authorBerg, Marcella C.pt_BR
dc.contributor.authorIles, Gail N.pt_BR
dc.contributor.authorSouza, Nicolas R. dept_BR
dc.contributor.authorJalarvo, Niina H.pt_BR
dc.contributor.authorBotosso, Viviane Fongaropt_BR
dc.contributor.authorSant'Anna, Osvaldo Augusto Brazil Estevespt_BR
dc.contributor.authorFantini, Marcia C. A.pt_BR
dc.contributor.authorBordallo, Heloisa N.pt_BR
dc.date.accessioned2020-07-09T21:23:35Z-
dc.date.available2020-07-09T21:23:35Z-
dc.date.issued2019pt_BR
dc.identifier.citationRasmussen MK., Pereira JE.M., Berg MC., Iles GN., Souza NR., Jalarvo NH., et al. Dynamics of encapsulated hepatitis B surface antigen: a combined neutron spectroscopy and thermo-analysis study. Eur Phys J Spec Top. 2019 Mar:227(17):2393-2399. doi:10.1140/epjst/e2019-700103-x.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2718-
dc.description.abstractAs a consequence of its ordered pore architecture, mesoporous SBA-15 offers new possibilities for incorporating biological agents. Considering its applicability in oral vaccination, which shows more beneficial features when compared with parenteral vaccines, SBA-15 is also seen as a very promising adjuvant to carry, protect, and deliver entrapped antigens. Recent studies have shown several remarkable features in the immunization of hepatitis B, a viral disease transmitted mainly through blood or serum transfer. However, the surface antigen of the hepatitis B virus, HBsAg, is too large to fit inside the SBA-15 matrix with mean pore diameter around 10 nm, thus raising the question of how SBA-15 can protect the antigen. In this work, thermal analysis combined with neutron spectroscopy allowed us to shed light on the interactions between HBsAg and SBA-15 as well as on the role that these interactions play in the efficiency of this promising oral vaccination method. This information was obtained by verifying how the dynamic behaviour of the antigen is modified under confinement in SBA-15, thus also establishing an experimental method for verifying molecular dynamics simulations.pt_BR
dc.description.sponsorshipDanish Agency for Science, Technology and Innovationpt_BR
dc.description.sponsorshipCiências sem Fronteiraspt_BR
dc.description.sponsorshipCoNext projectpt_BR
dc.description.sponsorshipCarlsbergfondpt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extentp. 2393-2399pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofThe European Physical Journal. Special Topicspt_BR
dc.titleDynamics of encapsulated hepatitis B surface antigen: a combined neutron spectroscopy and thermo-analysis studypt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1140/epjst/e2019-700103-xpt_BR
dc.identifier.urlhttp://dx.doi.org/10.1140/epjst/e2019-700103-xpt_BR
dc.contributor.externalUniversity of Copenhagen¦¦Dinamarcapt_BR
dc.contributor.externalEuropean Spallation Source (ESS)¦¦Suéciapt_BR
dc.contributor.externalRoyal Melbourne Institute of Technology University (RMIT University)¦¦Austráliapt_BR
dc.contributor.externalAustralia's Nuclear Science and Technology Organisation (ANSTO)¦¦Austráliapt_BR
dc.contributor.externalOak Ridge National Laboratory (ORNL)¦¦Estados Unidospt_BR
dc.contributor.externalForschungszentrum Jülich¦¦Alemanhapt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.identifier.citationvolume227pt_BR
dc.identifier.citationissuen. 17pt_BR
dc.relation.ispartofabbreviatedEur Phys J Spec Toppt_BR
dc.identifier.citationabntv. 227, n. 17, p. 2393-2399, mar. 2019pt_BR
dc.identifier.citationvancouver2019 Mar:227(17):2393-2399pt_BR
dc.contributor.butantanBotosso, Viviane Fongaro|:Pesquisador|:Lab. Virologia|:pt_BR
dc.contributor.butantanSant'Anna, Osvaldo Augusto Brazil Esteves|:Pesquisador|:Lab. Imunoquímica|:pt_BR
dc.sponsorship.butantanCarlsbergfond¦¦2013-01-0589pt_BR
dc.sponsorship.butantanCarlsbergfond¦¦CF14-0230pt_BR
dc.sponsorship.butantanCiências sem Fronteiras¦¦207740/2014-3pt_BR
dc.sponsorship.butantanCoNext project¦¦pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦pt_BR
dc.sponsorship.butantanDanish Agency for Science, Technology and Innovation¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
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item.languageiso639-1English-
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