Intracellular peptides in cell biology and pharmacology

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dc.contributorCentro de Toxinas, Resposta-imune e Sinalização Celular (CeTICS)pt_BR
dc.contributorLaboratório Especial de Ciclo Celularpt_BR
dc.contributor.authorde Araujo, Christiane Bezerrapt_BR
dc.contributor.authorHeimann, Andrea S.pt_BR
dc.contributor.authorRemer, Ricardo A.pt_BR
dc.contributor.authorRusso, Lilian C.pt_BR
dc.contributor.authorColquhoun, Alisonpt_BR
dc.contributor.authorForti, Fabio L.pt_BR
dc.contributor.authorFerro, Emer S.pt_BR
dc.date.accessioned2020-07-09T21:23:43Z-
dc.date.available2020-07-09T21:23:43Z-
dc.date.issued2019-
dc.identifier.citationde Araujo CB, Heimann AS., Remer RA., Russo LC., Colquhoun A, Forti FL., et al. Intracellular peptides in cell biology and pharmacology. Biomolecules. 2019 Apr;9(4),150. doi:10.3390/biom9040150.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2730-
dc.description.abstractIntracellular peptides are produced by proteasomes following degradation of nuclear, cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases generating a larger pool of peptides within cells. Thousands of intracellular peptides have been sequenced in plants, yeast, zebrafish, rodents, and in human cells and tissues. Relative levels of intracellular peptides undergo changes in human diseases and also when cells are stimulated, corroborating their biological function. However, only a few intracellular peptides have been pharmacologically characterized and their biological significance and mechanism of action remains elusive. Here, some historical and general aspects on intracellular peptides’ biology and pharmacology are presented. Hemopressin and Pep19 are examples of intracellular peptides pharmacologically characterized as inverse agonists to cannabinoid type 1 G-protein coupled receptors (CB1R), and hemopressin fragment NFKF is shown herein to attenuate the symptoms of pilocarpine-induced epileptic seizures. Intracellular peptides EL28 (derived from proteasome 26S protease regulatory subunit 4; Rpt2), PepH (derived from Histone H2B type 1-H), and Pep5 (derived from G1/S-specific cyclin D2) are examples of peptides that function intracellularly. Intracellular peptides are suggested as biological functional molecules, and are also promising prototypes for new drug development.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extentp. 150pt_BR
dc.languageengpt_BR
dc.relation.ispartofBiomoleculespt_BR
dc.rightsOpen Accesspt_BR
dc.titleIntracellular peptides in cell biology and pharmacologypt_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/biom9040150pt_BR
dc.identifier.urlhttps://doi.org/10.3390/biom9040150pt_BR
dc.contributor.externalProteimax Biotecnologia¦¦Brasilpt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalRemer Consultores¦¦Brasilpt_BR
dc.identifier.citationvolume9pt_BR
dc.identifier.citationissue4pt_BR
dc.subject.keywordintracellular peptidespt_BR
dc.subject.keywordproteasomept_BR
dc.subject.keywordepilepsypt_BR
dc.subject.keywordendocannabinoidpt_BR
dc.subject.keywordcancerpt_BR
dc.subject.keyworddrug discoverypt_BR
dc.subject.keywordobesitypt_BR
dc.subject.keywordinsulin resistancept_BR
dc.relation.ispartofabbreviatedBiomoleculespt_BR
dc.identifier.citationabntv. 9, n. 4, p. 150, abr. 2019pt_BR
dc.identifier.citationvancouver2019 Apr;9(4),150pt_BR
dc.contributor.butantanDe Araujo, Christiane Bezerra|:Aluno|:Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICS)|:PrimeiroAutorpt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦445363/2014-2pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦400944/2014-6pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦302809/2016-3pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦150077/2015-7pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦449390-4pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2004/04933-2pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2016/04000-3pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextembargo_29990101-
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