Functional variability of Bothrops atrox venoms from three distinct areas across the Brazilian Amazon and consequences for human envenomings

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dc.contributorLab. Imunopatologiapt_BR
dc.contributorLab. Herpetologiapt_BR
dc.contributorMuseu Biológicopt_BR
dc.contributor.authorDel Rei, Tiago Henrique Morettopt_BR
dc.contributor.authorSousa, Leijiane Figueira dept_BR
dc.contributor.authorFreitas-de-Sousa, Luciana Aparecidapt_BR
dc.contributor.authorMoura-da-Silva, Ana Mariapt_BR
dc.contributor.authorRocha, Marisa Maria Teixeira dapt_BR
dc.contributor.authorGrego, Kathleen Fernandespt_BR
dc.contributor.authorSant'Anna, Sávio Stefaninipt_BR
dc.contributor.authorTravaglia-Cardoso, Silvia Reginapt_BR
dc.contributor.authorChalkidis, Hipocrates M.pt_BR
dc.identifier.citationDel Rei THM, Sousa LF, Freitas-de-Sousa LA, Moura-da-Silva AM, Rocha MMT, Grego KF, et al. Functional variability of Bothrops atrox venoms from three distinct areas across the Brazilian Amazon and consequences for human envenomings. Toxicon. 2019 Jun;164:61-70. doi:10.1016/j.toxicon.2019.04.001.pt_BR
dc.description.abstractVariability in the composition of snake venoms occurs in different taxa and is usually correlated to snake fitness. Here, we compared B. atrox venoms from three different geographic regions across the Brazilian Amazon and found remarkable functional differences particularly between venoms from two populations separated by the Amazon River, in specimens born, raised and maintained under the same conditions at Instituto Butantan serpentary. Venom from Presidente Figueiredo snakes induced stronger dermonecrosis, but was less procoagulant and lethal to mice; these activities were correlated to the presence of a PI-class SVMP and absence of a SVSP in the venom, respectively. Venom from São Bento snakes was more hemorrhagic, killed mice more efficiently, but induced lower signs of dermonecrosis, which was correlated to the higher proportion of SVMPs and the absence of a PI-class SVMP isoform. Belterra snakes, a reference of wild snakes, presented venoms with intermediate phenotypes. Commercial Bothrops antivenom was effective in neutralizing all biological activities evaluated in this study, including dermonecrosis and pro-coagulant, which are relevant for human snakebite accidents by B. atrox. Functional differences correlated to snake fitness may also imply in different symptomatology for B. atrox snakebite patients and deserve special attention from clinical toxicologists.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.titleFunctional variability of Bothrops atrox venoms from three distinct areas across the Brazilian Amazon and consequences for human envenomingspt_BR
dc.contributor.externalUniversidade da Amazônia (UNAMA)¦¦Brasilpt_BR
dc.subject.keywordBothrops atroxpt_BR
dc.identifier.citationabntv. 164, p. 61-70, jun. 2019pt_BR
dc.identifier.citationvancouver2019 Jun;164:61-70pt_BR
dc.contributor.butantanDel Rei, Tiago Henrique Moretto|:Aluno|:Lab. Imunopatologia|:PrimeiroAutorpt_BR
dc.contributor.butantanMoura-da-Silva, Ana Maria|:Pesquisador:Docente Permanente PPGTOX|:Lab. Imunopatologia|:Autor de correspondênciapt_BR
dc.contributor.butantanSousa, Leijiane Figueira de|:Aluno|:Lab. Imunopatologia|:pt_BR
dc.contributor.butantanFreitas-de-Sousa, Luciana Aparecida|:Aluno|:Lab. Imunopatologia|:pt_BR
dc.contributor.butantanRocha, Marisa Maria Teixeira da|:Técnico|:Lab. Herpetologia|:pt_BR
dc.contributor.butantanGrego, Kathleen Fernandes|:Pesquisador|:Lab. Herpetologia|:pt_BR
dc.contributor.butantanSant'Anna, Sávio Stefanini|:Pesquisador|:Lab. Herpetologia|:pt_BR
dc.contributor.butantanTravaglia-Cardoso, Silvia Regina|:Pesquisador|:Museu Biológico|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦304.025/2014-3pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦063/2010pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2016/50.127-5pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/13.124-2pt_BR
dc.subject.researchlineToxinologia estruturalpt_BR
item.fulltextCom Texto completo-
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