Prolonged exposure of rats to varenicline increases anxiety and alters serotonergic system, but has no effect on memory

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dc.contributorLaboratório de Bioquímica e Biofísicapt_BR
dc.contributor.authorZaccarelli-Magalhães, Juliapt_BR
dc.contributor.authorSandini, Thaisa Meirapt_BR
dc.contributor.authorAbreu, Gabriel Ramos dept_BR
dc.contributor.authorPetrocelli, Bianca Mariapt_BR
dc.contributor.authorMoreira, Nataliapt_BR
dc.contributor.authorReis-Silva, Thiago Moirinhopt_BR
dc.contributor.authorLebrun, Ivopt_BR
dc.contributor.authorFlorio, Jorge Camilopt_BR
dc.contributor.authorRicci, Esther Lopespt_BR
dc.contributor.authorFukushima, André Rinaldipt_BR
dc.contributor.authorWaziry, Paula A. Fariapt_BR
dc.contributor.authorSpinosa, Helenice de Souzapt_BR
dc.identifier.citationZaccarelli-Magalhães J, Sandini TM, Abreu GR, Petrocelli BM, Moreira N, Reis-Silva TM, et al. Prolonged exposure of rats to varenicline increases anxiety and alters serotonergic system, but has no effect on memory. Pharmacol Biochem Behav. 2019 Jun;181;1-8. doi:10.1016/j.pbb.2019.03.009.pt_BR
dc.description.abstractVarenicline is a drug used for smoking addiction cessation treatment and acts as a partial agonist of nicotinic cholinergic receptors. Recent clinical trial data support use of varenicline for treatment of conditions/addictions that are not related to smoking cessation. Considering the importance of this issue and the need for new studies on its effects, especially on behavior, more studies using animal models are necessary. Thus, the aim of this study was to evaluate the effects of prolonged exposure to varenicline in anxiety-like behavior and memory, as well as in cerebral neurochemistry of rats. Male rats received three different doses of varenicline: 0.03 (therapeutic dose for humans), 0.1 and 0.3?mg/kg orally (gavage) for 30?days. Animal behavior was analyzed through open field, elevated plus maze, light/dark box, social interaction, Barnes maze and novel object recognition tests. Neurotransmitter levels and their metabolites in different brain structures (hippocampus, striatum and frontal cortex) were measured. Results showed that prolonged exposure of rats to varenicline: 1) did not interfere in motor activity, but caused an anxiogenic effect on elevated plus maze, light/dark box and social interaction testes; 2) did not alter memory; and 3) promoted alterations on serotoninergic system in the striatum and frontal cortex. In conclusion, compilation of the data indicates that prolonged exposure of rats to varenicline promoted anxiogenic effects and alteration in serotonergic system, which corroborated behavioral findings.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.format.extentp. 1-8pt_BR
dc.relation.ispartofPharmacology, Biochemistry and Behaviorpt_BR
dc.titleProlonged exposure of rats to varenicline increases anxiety and alters serotonergic system, but has no effect on memorypt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Presbiteriana Mackenzie¦¦Brasilpt_BR
dc.contributor.externalColégio de São Bento¦¦Brasilpt_BR
dc.contributor.externalNova Southeastern University¦¦EUApt_BR
dc.subject.keywordCholinergic receptorspt_BR
dc.subject.keywordCentral nervous systempt_BR
dc.relation.ispartofabbreviatedPharmacol Biochem Behavpt_BR
dc.identifier.citationabntv. 181, p. 1-8, jun. 2019pt_BR
dc.identifier.citationvancouver2019 Jun;181;1-8pt_BR
dc.contributor.butantanLebrun, Ivo|:Pesquisador:Docente Permanente PPGTOX|:Laboratório de Bioquímica e Biofísica|:Autor de correspondênciapt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦305500/2013-9pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/05049-3pt_BR
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