Shared species of crocodilian trypanosomes carried by tabanid flies in Africa and South America, including the description of a new species from caimans, Trypanosoma kaiowa n. sp.

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dc.contributorLab. Biologia Estruturalpt_BR
dc.contributor.authorFermino, Bruno R.pt_BR
dc.contributor.authorPaiva, Fernandopt_BR
dc.contributor.authorViola, Laerte B.pt_BR
dc.contributor.authorRodrigues, Carla M. F.pt_BR
dc.contributor.authorGarcia, Herakles A.pt_BR
dc.contributor.authorCampaner, Martapt_BR
dc.contributor.authorTakata, Carmen S. A.pt_BR
dc.contributor.authorSheferaw, Desiept_BR
dc.contributor.authorKisakye, John J.pt_BR
dc.contributor.authorKato, Agapituspt_BR
dc.contributor.authorJared, Carlospt_BR
dc.contributor.authorTeixeira, Marta M. G.pt_BR
dc.contributor.authorCamargo, Erney P.pt_BR
dc.date.accessioned2020-07-09T21:23:59Z-
dc.date.available2020-07-09T21:23:59Z-
dc.date.issued2019pt_BR
dc.identifier.citationFermino BR., Paiva F, Viola LB., Rodrigues CM.F., Garcia HA., Campaner M, et al. Shared species of crocodilian trypanosomes carried by tabanid flies in Africa and South America, including the description of a new species from caimans, Trypanosoma kaiowa n. sp.. Parasit. vectors.. 2019;12:225. doi:10.1186/s13071-019-3463-2.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2750-
dc.description.abstractBackground The genus Trypanosoma Gruby, 1843 is constituted by terrestrial and aquatic phylogenetic lineages both harboring understudied trypanosomes from reptiles including an increasing diversity of crocodilian trypanosomes. Trypanosoma clandestinus Teixeira & Camargo, 2016 of the aquatic lineage is transmitted by leeches to caimans. Trypanosoma grayi Novy, 1906 of the terrestrial lineage is transmitted by tsetse flies to crocodiles in Africa, but the vectors of Neotropical caiman trypanosomes nested in this lineage remain unknown. Results Our phylogenetic analyses uncovered crocodilian trypanosomes in tabanids from South America and Africa, and trypanosomes other than T. grayi in tsetse flies. All trypanosomes found in tabanids clustered in the crocodilian clade (terrestrial lineage) forming six clades: Grayi (African trypanosomes from crocodiles and tsetse flies); Ralphi (trypanosomes from caimans, African and Brazilian tabanids and tsetse flies); Terena (caimans); Cay03 (caimans and Brazilian tabanids); and two new clades, Tab01 (Brazilian tabanid and tsetse flies) and Kaiowa. The clade Kaiowa comprises Trypanosoma kaiowa n. sp. and trypanosomes from African and Brazilian tabanids, caimans, tsetse flies and the African dwarf crocodile. Trypanosoma kaiowa n. sp. heavily colonises tabanid guts and differs remarkably in morphology from other caiman trypanosomes. This species multiplied predominantly as promastigotes on log-phase cultures showing scarce epimastigotes and exhibited very long flagellates in old cultures. Analyses of growth behavior revealed that insect cells allow the intracellular development of Trypanosoma kaiowa n. sp. Conclusions Prior to this description of Trypanosoma kaiowa n. sp., no crocodilian trypanosome parasitic in tabanid flies had been cultured, morphologically examined by light, scanning and transmission microscopy, and phylogenetically compared with other crocodilian trypanosomes. Additionally, trypanosomes thought to be restricted to caimans were identified in Brazilian and African tabanids, tsetse flies and the dwarf crocodile. Similar repertoires of trypanosomes found in South American caimans, African crocodiles and tabanids from both continents support the recent diversification of these transcontinental trypanosomes. Our findings are consistent with trypanosome host-switching likely mediated by tabanid flies between caimans and transoceanic migrant crocodiles co-inhabiting South American wetlands at the Miocene.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipInstituto Nacional de Epidemiologia da Amazônia Ocidental (INCT-EPIAMO)pt_BR
dc.format.extent225pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofParasites & Vectorspt_BR
dc.rightsOpen Accesspt_BR
dc.titleShared species of crocodilian trypanosomes carried by tabanid flies in Africa and South America, including the description of a new species from caimans, Trypanosoma kaiowa n. sp.pt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1186/s13071-019-3463-2pt_BR
dc.identifier.urlhttps://doi.org/10.1186/s13071-019-3463-2pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal de Mato Grosso do Sul (UFMS)¦¦Brasilpt_BR
dc.contributor.externalArcadis¦¦Brasilpt_BR
dc.contributor.externalInstituto Nacional de Ciência e Tecnologia de Epidemiologia da Amazônia Ocidental (INCT-EPIAMO)¦¦Brasilpt_BR
dc.contributor.externalHawassa University¦¦Etiópiapt_BR
dc.contributor.externalMakerere University¦¦Ugandapt_BR
dc.contributor.externalUganda Virus Research Institute¦¦Ugandapt_BR
dc.identifier.citationvolume12pt_BR
dc.subject.keywordTabanidspt_BR
dc.subject.keywordTsetse fliept_BR
dc.subject.keywordCrocodilept_BR
dc.subject.keywordCaimapt_BR
dc.subject.keywordEvolutionpt_BR
dc.subject.keywordTaxonomypt_BR
dc.subject.keywordMorphologypt_BR
dc.subject.keywordTransoceanic dispersalpt_BR
dc.relation.ispartofabbreviatedParasit vectorspt_BR
dc.identifier.citationabntv. 12, 225, 2019pt_BR
dc.identifier.citationvancouver2019;12:225pt_BR
dc.contributor.butantanJared, Carlos|:Pesquisador:Docente Permanente PPGTOX|:Lab. Biologia Estrutural|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2016/07487-0pt_BR
dc.sponsorship.butantanInstituto Nacional de Epidemiologia da Amazônia Ocidental (INCT-EPIAMO)¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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