Evidence for snake venom plasticity in a long-term study with individual captive Bothrops atrox

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dc.contributorLab. Imunopatologiapt_BR
dc.contributor.authorAmazonas, Diana Rêgopt_BR
dc.contributor.authorFreitas-de-Sousa, Luciana Aparecidapt_BR
dc.contributor.authorOréfice, Daniele Pereirapt_BR
dc.contributor.authorSousa, Leijiane Figueira dept_BR
dc.contributor.authorMartinez, Melissa G.pt_BR
dc.contributor.authorMourao, Rosa H. V.pt_BR
dc.contributor.authorChalkidis, Hipocrates M.pt_BR
dc.contributor.authorCamargo, Plínio B.pt_BR
dc.contributor.authorMoura-da-Silva, Ana Mariapt_BR
dc.date.accessioned2020-07-09T21:24:21Z-
dc.date.available2020-07-09T21:24:21Z-
dc.date.issued2019pt_BR
dc.identifier.citationAmazonas DR, Freitas-de-Sousa LA, Oréfice DP, Sousa LF, Martinez MG., Mourao RH.V., et al. Evidence for snake venom plasticity in a long-term study with individual captive Bothrops atrox. Toxins. 2019 May;11(5):294. doi:10.3390/toxins11050294.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2777-
dc.description.abstractVariability in snake venom composition has been frequently reported and correlated to the adaptability of snakes to environmental conditions. Previous studies report plasticity for the venom phenotype. However, these observations are not conclusive, as the results were based on pooled venoms, which present high individual variability. Here we tested the hypothesis of plasticity by influence of confinement and single diet type in the venom composition of 13 adult specimens of Bothrops atrox snakes, maintained under captivity for more than three years. Individual variability in venom composition was observed in samples extracted just after the capture of the snakes. However, composition was conserved in venoms periodically extracted from nine specimens, which presented low variability restricted to the less abundant components. In a second group, composed of four snakes, drastic changes were observed in the venom samples extracted at different periods, mostly related to snake venom metalloproteinases (SVMPs), the core function toxins of B. atrox venom, which occurred approximately between 400 and 500 days in captivity. These data show plasticity in the venom phenotype during the lifetime of adult snakes maintained under captive conditions. Causes or functional consequences involved in the phenotype modification require further investigations.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent294pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxinspt_BR
dc.rightsOpen Accesspt_BR
dc.titleEvidence for snake venom plasticity in a long-term study with individual captive Bothrops atroxpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/toxins11050294pt_BR
dc.identifier.urlhttps://doi.org/10.3390/toxins11050294pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal do Oeste do Pará (UFOPA)¦¦Brasilpt_BR
dc.contributor.externalUniversidade da Amazônia (UNAMA)¦¦Brasilpt_BR
dc.identifier.citationvolume11pt_BR
dc.identifier.citationissue5pt_BR
dc.subject.keywordvenom variabilitypt_BR
dc.subject.keywordmetalloproteinasespt_BR
dc.subject.keywordenzyme toxinspt_BR
dc.relation.ispartofabbreviatedToxinspt_BR
dc.identifier.citationabntv. 11, n. 5, 294, mai. 2019pt_BR
dc.identifier.citationvancouver2019 May;11(5):294pt_BR
dc.contributor.butantanAmazonas, Diana Rêgo|:Aluno|:Lab. Imunopatologia|:PrimeiroAutorpt_BR
dc.contributor.butantanMoura-da-Silva, Ana Maria|:Pesquisador:Docente Permanente PPGTOX|:Lab. Imunopatologia|:Autor de correspondênciapt_BR
dc.contributor.butantanFreitas-de-Sousa, Luciana Aparecida|:Aluno|:Lab. Imunopatologia|:pt_BR
dc.contributor.butantanOréfice, Daniele Pereira|:Técnico|:Lab. Imunopatologia|:pt_BR
dc.contributor.butantanSousa, Leijiane Figueira de|:Aluno|:Lab. Imunopatologia|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦303958/2018-9pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦063/2010pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2016/50127-5pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/24564-3pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/13124-2pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.subject.researchlineToxinologia estruturalpt_BR
dc.description.dbindexedYespt_BR
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