Effects of the natural peptide crotamine from a south american rattlesnake on Candida auris, an emergent multidrug antifungal resistant human pathogen

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dc.contributorLaboratório Especial de Toxinologia Aplicada (LETA)pt_BR
dc.contributor.authorMas, Caroline Dalpt_BR
dc.contributor.authorRossato, Luanapt_BR
dc.contributor.authorShimizu, Thaíspt_BR
dc.contributor.authorOliveira, Eduardo B.pt_BR
dc.contributor.authorSilva Junior, Pedro Ismael dapt_BR
dc.contributor.authorMeis, Jacques F.pt_BR
dc.contributor.authorColombo, Arnaldo Lopespt_BR
dc.contributor.authorHayashi, Mirian A. F.pt_BR
dc.date.accessioned2020-07-09T21:24:22Z-
dc.date.available2020-07-09T21:24:22Z-
dc.date.issued2019-
dc.identifier.citationMas CD, Rossato L, Shimizu T, Oliveira EB., Silva Junior PI, Meis JF., et al. Effects of the natural peptide crotamine from a south american rattlesnake on Candida auris, an emergent multidrug antifungal resistant human pathogen. Biomolecules. 2019 May;9(6):205. doi:10.3390/biom9060205.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2778-
dc.description.abstractInvasive Candida infections are an important growing medical concern and treatment options are limited to a few antifungal drug classes, with limited efficacies depending on the infecting organism. In this scenario, invasive infections caused by multiresistant Candida auris are emerging in several places around the world as important healthcare-associated infections. As antimicrobial peptides (AMPs) exert their activities primarily through mechanisms involving membrane disruption, they have a lower chance of inducing drug resistance than general chemical antimicrobials. Interestingly, we previously described the potent candicidal effect of a rattlesnake AMP, crotamine, against standard and treatment-resistant clinical isolates, with no hemolytic activity. We evaluated the antifungal susceptibility of several Candida spp. strains cultured from different patients by using the Clinical and Laboratory Standards Institute (CLSI) microdilution assay, and the antifungal activity of native crotamine was evaluated by a microbial growth inhibition microdilution assay. Although all Candida isolates evaluated here showed resistance to amphotericin B and fluconazole, crotamine (40–80 µM) exhibited in vitro activity against most isolates tested. We suggest that this native polypeptide from the South American rattlesnake Crotalus durissus terrificus has potential as a structural model for the generation of a new class of antimicrobial compounds with the power to fight against multiresistant Candida spp.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent205pt_BR
dc.languageengpt_BR
dc.relation.ispartofBiomoleculespt_BR
dc.rightsOpen Accesspt_BR
dc.titleEffects of the natural peptide crotamine from a south american rattlesnake on Candida auris, an emergent multidrug antifungal resistant human pathogenpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/biom9060205pt_BR
dc.identifier.urlhttps://doi.org/10.3390/biom9060205pt_BR
dc.contributor.externalUniversidade Federal de São Paulo (UNIFESP)¦¦Brasilpt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalCanisius-Wilhelmina Hospital (CWZ)¦¦Netherlandspt_BR
dc.identifier.citationvolume9pt_BR
dc.identifier.citationissue6pt_BR
dc.subject.keywordrattlesnake venom toxinpt_BR
dc.subject.keywordcrotaminept_BR
dc.subject.keywordantimicrobial peptidept_BR
dc.subject.keywordmultiresistant strainpt_BR
dc.subject.keywordfunguspt_BR
dc.subject.keywordCandida spppt_BR
dc.relation.ispartofabbreviatedBiomoleculespt_BR
dc.identifier.citationabntv. 9, n. 6, 209, maio 2019pt_BR
dc.identifier.citationvancouver2019 May;9(6):205pt_BR
dc.contributor.butantanSilva Junior, Pedro Ismael da|:Pesquisador|:Laboratório Especial de Toxinologia Aplicada (LETA)|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦311815/2012-0pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦475739/2013-2pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦39337/2016-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/13392-4pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/02413-1pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
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