Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity

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dc.contributorCentro de Biotecnologiapt_BR
dc.contributorLEDV - Laboratório de Desenvolvimento de Vacinaspt_BR
dc.contributor.authorFarias, Leonardo Paivapt_BR
dc.contributor.authorChalmers, Iain W.pt_BR
dc.contributor.authorPerally, Samirahpt_BR
dc.contributor.authorRofatto, Henrique Krambeckpt_BR
dc.contributor.authorJackson, Colin J.pt_BR
dc.contributor.authorBrown, Marthapt_BR
dc.contributor.authorKhouri, Mariana I.pt_BR
dc.contributor.authorBarbosa, Mayra Mara Ferraript_BR
dc.contributor.authorHensbergen, Paul J.pt_BR
dc.contributor.authorHokke, Cornelis H.pt_BR
dc.contributor.authorLeite, Luciana Cezar de Cerqueirapt_BR
dc.contributor.authorHoffmann, Karl F.pt_BR
dc.date.accessioned2020-07-09T21:24:34Z-
dc.date.available2020-07-09T21:24:34Z-
dc.date.issued2019pt_BR
dc.identifier.citationFarias LP, Chalmers IW., Perally S, Rofatto HK, Jackson CJ., Brown M, et al. Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity. Int. J. Parasitol.. 2019 Jul;49(8):593-599. doi:10.1016/j.ijpara.2019.03.003.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2793-
dc.description.abstractSchistosoma mansoni venom allergen-like proteins (SmVALs) are part of a diverse protein superfamily partitioned into two groups (group 1 and group 2). Phylogenetic analyses of group 1 SmVALs revealed that members could be segregated into subclades (A–D); these subclades share similar gene expression patterns across the parasite lifecycle and immunological cross-reactivity. Furthermore, whole-mount in situ hybridization demonstrated that the phylogenetically, transcriptionally and immunologically-related SmVAL4, 10, 18 and 19 (subclade C) were all localized to the pre-acetabular glands of immature cercariae. Our results suggest that SmVAL group 1 phylogenetic relationships, stage-specific transcriptional profiles and tissue localization are predictive of immunological cross-reactivity.pt_BR
dc.description.sponsorshipWellcome Trustpt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.format.extentp.593-599pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofInternational Journal For Parasitologypt_BR
dc.rightsOpen Accesspt_BR
dc.titleSchistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivitypt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.ijpara.2019.03.003pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.ijpara.2019.03.003pt_BR
dc.contributor.externalFundação Oswaldo Cruz (Fiocruz)¦¦Brasilpt_BR
dc.contributor.externalAberystwyth University¦¦Reino Unidopt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalLeiden University Medical Centre¦¦Países Baixospt_BR
dc.identifier.citationvolume49pt_BR
dc.identifier.citationissue8pt_BR
dc.subject.keywordVenom allergen-likept_BR
dc.subject.keywordImmunological cross reactivitypt_BR
dc.subject.keywordTissue localizationpt_BR
dc.subject.keywordSchistosoma mansonipt_BR
dc.relation.ispartofabbreviatedInt J Parasitolpt_BR
dc.identifier.citationabntv. 49, n. 8, p. 593-599, jul. 2019pt_BR
dc.identifier.citationvancouver2019 Jul;49(8):593-599pt_BR
dc.contributor.butantanFarias, Leonardo Paiva|:Aluno|:Centro de Biotecnologia|:PrimeiroAutorpt_BR
dc.contributor.butantanRofatto, Henrique Krambeck|:Aluno|:Centro de Biotecnologia|:pt_BR
dc.contributor.butantanBarbosa, Mayra Mara Ferrari|:Aluno|:LEDV - Laboratório de Desenvolvimento de Vacinas|:pt_BR
dc.contributor.butantanLeite, Luciana Cezar de Cerqueira|:Pesquisador|:LEDV - Laboratório de Desenvolvimento de Vacinas|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦160861/2017-9pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦001pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2012/23124-4pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2008/57946-5pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2007/07685-8pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦FAPESP 00/11624-5pt_BR
dc.sponsorship.butantanWellcome Trust¦¦WT084273/Z/07/Zpt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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