Analysis of the snake venom peptidome

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Snake venom peptidomes are known to be a large source of molecules with different pharmacological properties. The complexity and variability of snake venoms, the presence of proteinases, and the lack of complete species-specific genome sequences make snake venom peptidome profiling a challenging task that requires especial technical strategies for sample processing and mass spectrometric analysis. Here we describe a method for assessing the content of snake venom peptides and highlight the importance of sampling procedures, as they substantially influence the peptidomic complexity of snake venoms.
Serrano SMT, Kitano ES, Zelanis A, Tashima AK.. Analysis of the snake venom peptidome. Methods Mol Biol. 2018;1719: 349-358. doi:10.1007/978-1-4939-7537-2_23.
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