Analysis of the snake venom peptidome
Snake venom peptidomes are known to be a large source of molecules with different pharmacological properties. The complexity and variability of snake venoms, the presence of proteinases, and the lack of complete species-specific genome sequences make snake venom peptidome profiling a challenging task that requires especial technical strategies for sample processing and mass spectrometric analysis. Here we describe a method for assessing the content of snake venom peptides and highlight the importance of sampling procedures, as they substantially influence the peptidomic complexity of snake venoms.
Snake venom; Peptidome; Solid-phase extraction; Proteinase inhibition; Mass spectrometry
Serrano SMT, Kitano ES, Zelanis A, Tashima AK.. Analysis of the snake venom peptidome. Methods Mol Biol. 2018;1719: 349-358. doi:10.1007/978-1-4939-7537-2_23.
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