Progress in mucosal immunization for protection against pneumococcal pneumonia

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dc.contributorLaboratório de Desenvolvimento de Vacinaspt_BR
dc.contributorLab. Bacteriologiapt_BR
dc.contributor.authorGonçalves, Viviane Maimonipt_BR
dc.contributor.authorKaneko, Kanpt_BR
dc.contributor.authorSolórzano, Carlapt_BR
dc.contributor.authorMacLoughlin, Ronanpt_BR
dc.contributor.authorSaleem, Imranpt_BR
dc.contributor.authorMiyaji, Eliane Namiept_BR
dc.date.accessioned2020-07-09T21:24:58Z-
dc.date.available2020-07-09T21:24:58Z-
dc.date.issued2019pt_BR
dc.identifier.citationGonçalves VM, Kaneko K, Solórzano C, MacLoughlin R, Saleem I, Miyaji EN. Progress in mucosal immunization for protection against pneumococcal pneumonia. Expert Rev. Vaccines. 2019 Jul;18(8):781-792. doi:10.1080/14760584.2019.1643719.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2823-
dc.description.abstractIntroduction: Lower respiratory tract infections are the fourth cause of death worldwide and pneumococcus is the leading cause of pneumonia. Nonetheless, existing pneumococcal vaccines are less effective against pneumonia than invasive diseases and serotype replacement is a major concern. Protein antigens could induce serotype-independent protection, and mucosal immunization could offer local and systemic immune responses and induce protection against pneumococcal colonization and lung infection. Areas covered: Immunity induced in the experimental human pneumococcal carriage model, approaches to address the physiological barriers to mucosal immunization and improve delivery of the vaccine antigens, different strategies already tested for pneumococcal mucosal vaccination, including live recombinant bacteria, nanoparticles, bacterium-like particles, and nanogels as well as, nasal, pulmonary, sublingual and oral routes of vaccination. Expert opinion: The most promising delivery systems are based on nanoparticles, bacterial-like particles or nanogels, which possess greater immunogenicity than the antigen alone and are considered safer than approaches based on living cells or toxoids. These particles can protect the antigen from degradation, eliminating the refrigeration need during storage and allowing the manufacture of dry powder formulations. They can also increase antigen uptake, control release of antigen and trigger innate immune responses.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipBactiVacpt_BR
dc.format.extent781-792pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofExpert Review of Vaccinespt_BR
dc.titleProgress in mucosal immunization for protection against pneumococcal pneumoniapt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1080/14760584.2019.1643719pt_BR
dc.identifier.urlhttps://doi.org/10.1080/14760584.2019.1643719pt_BR
dc.contributor.externalLiverpool John Moores University (LJMU)¦¦Reino Unidopt_BR
dc.contributor.externalLiverpool School of Tropical Medicine (LSTM)¦¦Reino Unidopt_BR
dc.contributor.externalAerogen¦¦Irlandapt_BR
dc.identifier.citationvolume18pt_BR
dc.identifier.citationissue9pt_BR
dc.subject.keywordStreptococcus pneumoniaept_BR
dc.subject.keywordpneumococcal surface protein Apt_BR
dc.subject.keywordserotype-independent pneumococcal vaccinespt_BR
dc.subject.keywordexperimental human pneumococcal carriagept_BR
dc.subject.keywordnanoparticlespt_BR
dc.subject.keywordbacterial-like particlespt_BR
dc.subject.keywordnanogelspt_BR
dc.subject.keywordlive recombinant bacteriapt_BR
dc.subject.keywordouter membrane vesiclespt_BR
dc.relation.ispartofabbreviatedExpert Rev Vaccinespt_BR
dc.identifier.citationabntv. 18, n. 8, p. 781-792, Jul. 2019pt_BR
dc.identifier.citationvancouver2019 Jul;18(8):781-792pt_BR
dc.contributor.butantanGonçalves, Viviane Maimoni|:Pesquisador|:Laboratório de Desenvolvimento de Vacinas|:PrimeiroAutor:Autor de correspondênciapt_BR
dc.contributor.butantanMiyaji, Eliane Namie|:Pesquisador|:Lab. Bacteriologia|:pt_BR
dc.sponsorship.butantanBactiVac¦¦BVNCP-02pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2016/50413-8pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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item.languageiso639-1English-
item.openairetypeArticle-
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