Serrulin: a glycine-rich bioactive peptide from the hemolymph of the yellow Tityus serrulatus scorpion

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dc.contributorLETA - Laboratório de Toxinologia Aplicadapt_BR
dc.contributor.authorOliveira, Thiago de Jesuspt_BR
dc.contributor.authorOliveira, Ursula Castro dept_BR
dc.contributor.authorSilva Junior, Pedro Ismael dapt_BR
dc.date.accessioned2020-07-09T21:25:14Z-
dc.date.available2020-07-09T21:25:14Z-
dc.date.issued2019pt_BR
dc.identifier.citationOliveira TJ, Oliveira UC, Silva Junior PI. Serrulin: a glycine-rich bioactive peptide from the hemolymph of the yellow Tityus serrulatus scorpion. Toxins. 2019 Sep;11(9):517. doi:10.3390/toxins11090517.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2841-
dc.description.abstractAntimicrobial peptides (AMPs) are small molecules, which have a potential use as antibiotic or pharmacological tools. In chelicerate organisms, such as scorpions, these molecules constitute an alternative defense system against microorganisms. The aim of this work was to identify AMPs in the hemolymph of the Tityus serrulatus scorpion. Fractions of plasma and hemocytes were subjected to high-performance liquid chromatography (HPLC) and then analyzed to determine their activity in inhibiting microbial growth. One of the fractions from the hemocytes presents antimicrobial activity against microorganisms, such as Gram-negative and Gram-positive bacteria, fungi, and yeast. These fractions were analyzed by mass spectrometry, and a fragment of 3564 Da. was identified. The peptide was called serrulin, because it is derived from the species T. serrulatus. A comparison of the amino acid sequence of serrulin with databases shows that it has a similarity to the glycine-rich peptides described in Cupienius salai and Acanthoscurria gomesiana (spiders). Furthermore, serrulin has no hemolytic activity against human erythrocytes. While the presence of AMPs in T. serrulatus venom has been described in other works, this is the first work to characterize the presence of these molecules in the hemolymph (hemocytes) of this species and show its potential use as an alternative to conventional antibiotics against different species of microorganisms.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent517pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxinspt_BR
dc.rightsOpen Accesspt_BR
dc.titleSerrulin: a glycine-rich bioactive peptide from the hemolymph of the yellow Tityus serrulatus scorpionpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/toxins11090517pt_BR
dc.identifier.urlhttps://doi.org/10.3390/toxins11090517pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.identifier.citationvolume11pt_BR
dc.identifier.citationissue9pt_BR
dc.subject.keywordantimicrobial peptidept_BR
dc.subject.keywordglycine-rich peptidept_BR
dc.subject.keywordinnate immune systempt_BR
dc.subject.keywordscorpionspt_BR
dc.subject.keywordTityus serrulatuspt_BR
dc.relation.ispartofabbreviatedToxinspt_BR
dc.identifier.citationabntv. 11, n. 9, p. 517, sep. 2019pt_BR
dc.identifier.citationvancouver2019 Sep;11(9):517pt_BR
dc.contributor.butantanOliveira, Thiago de Jesus|:Aluno|:Laboratório Especial de Toxinologia Aplicada (LETA)|:PrimeiroAutor:Autor de correspondênciapt_BR
dc.contributor.butantanOliveira, Ursula Castro de|:Aluno|:Laboratório Especial de Toxinologia Aplicada (LETA)|:pt_BR
dc.contributor.butantanSilva Junior, Pedro Ismael da|:Pesquisador|:Laboratório Especial de Toxinologia Aplicada (LETA)|:Autor de correspondênciapt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦155303/2016-3pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦472744/2012-7pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/07467-1pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1English-
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crisitem.author.orcid0000-0002-4811-757X-
crisitem.author.orcid0000-0001-6619-6489-
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