B-1 cell-mediated modulation of M1 macrophage profile ameliorates microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi

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dc.contributorLab. Fisiopatologiapt_BR
dc.contributor.authorPereira, Adrianopt_BR
dc.contributor.authorAlvares-Saraiva, Anuska Marcelinopt_BR
dc.contributor.authorKonno, Fabiana Toshie de Camargopt_BR
dc.contributor.authorSpadacci-Morena, Diva Denellept_BR
dc.contributor.authorPerez, Elizabeth Cristinapt_BR
dc.contributor.authorMariano, Mariopt_BR
dc.contributor.authorLallo, Maria Anetept_BR
dc.date.accessioned2020-07-09T21:25:25Z-
dc.date.available2020-07-09T21:25:25Z-
dc.date.issued2019pt_BR
dc.identifier.citationPereira A, Alvares-Saraiva AM, Konno FTC, Spadacci-Morena DD, Perez EC, Mariano M, et al. B-1 cell-mediated modulation of M1 macrophage profile ameliorates microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi. PLoS negl. trop. dis.. 2019 Sep;13(9):e0007674. doi:10.1371/journal.pntd.0007674.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2855-
dc.description.abstractHere, we have investigated the possible effect of B-1 cells on the activity of peritoneal macrophages in E. cuniculi infection. In the presence of B-1 cells, peritoneal macrophages had an M1 profile with showed increased phagocytic capacity and index, associated with the intense microbicidal activity and a higher percentage of apoptotic death. The absence of B-1 cells was associated with a predominance of the M2 macrophages, reduced phagocytic capacity and index and microbicidal activity, increased pro-inflammatory and anti-inflammatory cytokines production, and higher percentual of necrosis death. In addition, in the M2 macrophages, spore of phagocytic E. cuniculi with polar tubular extrusion was observed, which is an important mechanism of evasion of the immune response. The results showed the importance of B-1 cells in the modulation of macrophage function against E. cuniculi infection, increasing microbicidal activity, and reducing the fungal mechanisms involved in the evasion of the immune responsept_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.format.extente0007674pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofPlos Neglected Tropical Diseasespt_BR
dc.rightsOpen Accesspt_BR
dc.titleB-1 cell-mediated modulation of M1 macrophage profile ameliorates microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculipt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1371/journal.pntd.0007674pt_BR
dc.identifier.urlhttps://doi.org/10.1371/journal.pntd.0007674pt_BR
dc.contributor.externalUniversidade Paulista (UNIP)¦¦Brasilpt_BR
dc.contributor.externalCentro Universitário São Camilo¦¦Brasilpt_BR
dc.contributor.externalUniversidade Cruzeiro do Sul (UNICSUL)¦¦Brasilpt_BR
dc.identifier.citationvolume13pt_BR
dc.identifier.citationissue9pt_BR
dc.relation.ispartofabbreviatedPLoS negl trop dispt_BR
dc.identifier.citationabntv. 13, n. 9, p. e0007674, sep. 2019pt_BR
dc.identifier.citationvancouver2019 Sep;13(9):e0007674pt_BR
dc.contributor.butantanAlvares-Saraiva, Anuska Marcelino|:Aluno|:Lab. Fisiopatologia|:pt_BR
dc.contributor.butantanSpadacci-Morena, Diva Denelle|:Pesquisador|:Lab. Fisiopatologia|:pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/25948-2pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1English-
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