Population structure and genetic diversity among isolates of coccidioides posadasii in Venezuela and surrounding regions

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dc.contributor(LCC) Lab. Ciclo Celularpt_BR
dc.contributor.authorTeixeira, Marcus Mpt_BR
dc.contributor.authorAlvarado, Primaverapt_BR
dc.contributor.authorRoe, Chandler Cpt_BR
dc.contributor.authorThompson, George Rpt_BR
dc.contributor.authorPatané, José Salvatore Leisterpt_BR
dc.contributor.authorSahl, Jason Wpt_BR
dc.contributor.authorKeim, Paulpt_BR
dc.contributor.authorGalgiani, John Npt_BR
dc.contributor.authorLitvintseva, Anastasia Ppt_BR
dc.contributor.authorMatute, Daniel Rpt_BR
dc.contributor.authorBarker, Bridget Mpt_BR
dc.date.accessioned2020-07-09T21:25:42Z-
dc.date.available2020-07-09T21:25:42Z-
dc.date.issued2019pt_BR
dc.identifier.citationTeixeira MM, Alvarado P, Roe CC, Thompson GR, Patané JSL, Sahl JW, et al. Population structure and genetic diversity among isolates of coccidioides posadasii in Venezuela and surrounding regions. MBio. 2019 Nov;10(6):e01976-19. doi:10.1128/mBio.01976-19.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2876-
dc.description.abstractCoccidioides posadasii is a pathogenic fungus that causes coccidioidomycosis in many arid regions of the Americas. One of these regions is bordered by the Caribbean Sea, and the surrounding landscape may play an important role in the dispersion of C. posadasii across South America through southeastern Mexico, Honduras, Guatemala, and Venezuela. Comparative phylogenomic analyses of C. posadasii reveal that clinical strains from Venezuela are genetically distinct from the North American populations found in (i) Arizona and (ii) Texas, Mexico, and the rest of South America (TX/MX/SA). We find evidence for admixture between the Venezuela and the North American populations of C. posadasii in Central America. Additionally, the proportion of Venezuelan alleles in the admixed population decreases as latitude (and distance from Venezuela) increases. Our results indicate that the population in Venezuela may have been subjected to a recent bottleneck and shows a strong population structure. This analysis provides insight into potential for Coccidioides spp. to invade new regions. IMPORTANCE Valley Fever is a fungal disease caused by two species of fungi: Coccidioides immitis and C. posadasii. These fungi are found throughout the arid regions of North and South America; however, our understanding of genetic diversity and disease in South America is limited. In this report, we analyze 10 new genomes of Coccidioides posadasii from regions bordering the Caribbean Sea. We show that these populations are distinct and that isolates from Venezuela are likely a result of a recent bottleneck. These data point to patterns that might be observed when investigating recently established populations.pt_BR
dc.description.sponsorship(NIH) National Institutes of Healthpt_BR
dc.format.extente01976-19pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofmBiopt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titlePopulation structure and genetic diversity among isolates of coccidioides posadasii in Venezuela and surrounding regionspt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.1128/mBio.01976-19pt_BR
dc.identifier.urlhttps://doi.org/10.1128/mBio.01976-19pt_BR
dc.contributor.external(NAU) Northern Arizona Universitypt_BR
dc.contributor.external(UNB) Universidade de Brasíliapt_BR
dc.contributor.externalInstituto de Biomedicina Dr. Jacinto Convitpt_BR
dc.contributor.externalUC Davis Medical Centerpt_BR
dc.contributor.externalCenters for Disease Control and Preventionpt_BR
dc.contributor.external(UNC) University of North Carolina at Chapel Hillpt_BR
dc.identifier.citationvolume10pt_BR
dc.identifier.citationissue6pt_BR
dc.subject.keywordcoccidioidomycosispt_BR
dc.subject.keywordVenezuelapt_BR
dc.subject.keywordCoccidioides posadasiipt_BR
dc.subject.keywordCaribbeanpt_BR
dc.subject.keywordValleypt_BR
dc.relation.ispartofabbreviatedMBiopt_BR
dc.identifier.citationabntv. 10, n. 6, p. e01976-19, nov. 2019pt_BR
dc.identifier.citationvancouver2019 Nov;10(6):e01976-19pt_BR
dc.contributor.butantanPatané, José Salvatore Leister|:Pesquisador|:LCC - Laboratório de Ciclo Celular|:pt_BR
dc.sponsorship.butantanNational Institutes of Health (NIH)¦¦R21AI28536pt_BR
dc.sponsorship.butantanNational Institutes of Health (NIH)¦¦R01GM121750pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.grantfulltextopen-
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