Carbonylative negishi-type coupling of 2-Iodoglycals with alkyl and aryl halides
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English
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Abstract
C-Glycosides are valuable organic compounds in the field of medicinal chemistry due to their ubiquity inside living systems and pronounced biological activity. Herein, we describe an approach to alkyl-ketones bearing glycal units via the Pd-catalyzed carbonylative coupling of 2-iodoglycals and alkyl and aryl halides. Examples bearing a variety of functional groups are presented as well as a mechanistic proposal for this transformation.
Reference
Esteves HA., Darbem MP., Pimenta DC, Stefani HA.. Carbonylative negishi-type coupling of 2-Iodoglycals with alkyl and aryl halides. European J. Org. Chem.. 2019 Nov;2019(44):7384-7388. doi:10.1002/ejoc.201901081.
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https://repositorio.butantan.gov.br/handle/butantan/2886
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https://doi.org/10.1002/ejoc.201901081
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2019
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Embargoed until January 1, 2999 Request a copy
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