When could human challenge trials be deployed to combat emerging infectious diseases? Lessons from the case of a Zika virus human challenge trial

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dc.contributorDivisão de Ensaios Clínicos e Farmacovigilânciapt_BR
dc.contributor.authorPalacios, Ricardopt_BR
dc.contributor.authorShah, Seema K.pt_BR
dc.date.accessioned2020-07-09T21:25:54Z-
dc.date.available2020-07-09T21:25:54Z-
dc.date.issued2019-
dc.identifier.citationPalacios R, Shah SK.. When could human challenge trials be deployed to combat emerging infectious diseases? Lessons from the case of a Zika virus human challenge trial. Trials. 2019 Dec;20(suppl. 2):702. doi:10.1186/s13063-019-3843-0.pt_BR
dc.identifier.issn1745-6215-
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2893-
dc.description.abstractHuman challenge trials (HCTs) deliberately infect participants in order to test vaccines and treatments in a controlled setting, rather than enrolling individuals with natural exposure to a disease. HCTs are therefore potentially powerful tools to prepare for future outbreaks of emerging infectious diseases. Yet when an infectious disease is emerging, there is often substantial risk and uncertainty about its complications, and few available interventions, making an HCT ethically complex. In light of the need to consider ethical issues proactively as a part of epidemic preparedness, we use the case of a Zika virus HCT to explore whether and when HCTs might be ethically justified to combat emerging infectious diseases. We conclude that emerging infectious diseases could be appropriate candidates for HCTs and we identify relevant considerations and provide a case example to illustrate when they might be ethically acceptable.pt_BR
dc.description.sponsorshipWellcome Trustpt_BR
dc.description.sponsorshipBill & Melinda Gates Foundationpt_BR
dc.description.sponsorshipNational Institutes of Health (NIH)pt_BR
dc.description.sponsorshipMedical Research Council (MRC)pt_BR
dc.format.extent702pt_BR
dc.languageengpt_BR
dc.publisherBioMed Centralpt_BR
dc.relation.ispartofTrialspt_BR
dc.rightsOpen Accesspt_BR
dc.titleWhen could human challenge trials be deployed to combat emerging infectious diseases? Lessons from the case of a Zika virus human challenge trialpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1186/s13063-019-3843-0pt_BR
dc.identifier.urlhttps://doi.org/10.1186/s13063-019-3843-0pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalNorthwestern University¦¦Estados Unidospt_BR
dc.contributor.externalAnn & Robert H. Lurie Children’s Hospital of Chicago¦¦Estados Unidospt_BR
dc.publisher.cityLondonpt_BR
dc.identifier.citationvolume20pt_BR
dc.identifier.citationissuesuppl. 2pt_BR
dc.subject.keywordHuman challenge trialspt_BR
dc.subject.keywordResearch ethicspt_BR
dc.subject.keywordEthics in emergenciespt_BR
dc.subject.keywordZika viruspt_BR
dc.relation.ispartofabbreviatedTrialspt_BR
dc.identifier.citationabntv. 20, suppl. 2, 702, dez. 2019pt_BR
dc.identifier.citationvancouver2019 Dec;20(suppl. 2):702pt_BR
dc.publisher.countryEnglandpt_BR
dc.contributor.butantanPalacios, Ricardo|:Pesquisador|:Divisão de Ensaios Clínicos e Farmacovigilância|:PrimeiroAutor:Autor de correspondênciapt_BR
dc.sponsorship.butantanBill & Melinda Gates Foundation¦¦OPP1151904pt_BR
dc.sponsorship.butantanMedical Research Council (MRC)¦¦pt_BR
dc.sponsorship.butantanNational Institutes of Health (NIH)¦¦pt_BR
dc.sponsorship.butantanWellcome Trust¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextembargo_29990101-
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