Bothrops atrox, the most important snake involved in human envenomings in the amazon: how venomics contributes to the knowledge of snake biology and clinical toxinology

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dc.contributorLETA - Laboratório de Toxinologia Aplicadapt_BR
dc.contributorLaboratório de Artrópodespt_BR
dc.contributorLab. Imunopatologiapt_BR
dc.contributor.authorMonteiro, Wuelton Marcelopt_BR
dc.contributor.authorContreras-Bernal, Jorge Carlospt_BR
dc.contributor.authorFerreira Bisneto, Pedropt_BR
dc.contributor.authorSachett, Jacquelinept_BR
dc.contributor.authorSilva, Iran Mendonça dapt_BR
dc.contributor.authorLacerda, Marcuspt_BR
dc.contributor.authorCosta, Allyson Guimarães dapt_BR
dc.contributor.authorVal, Fernandopt_BR
dc.contributor.authorBrasileiro, Liselept_BR
dc.contributor.authorSartim, Marco Auréliopt_BR
dc.contributor.authorSilva-de-Oliveira, Sâmellapt_BR
dc.contributor.authorBernarde, Paulo Sérgiopt_BR
dc.contributor.authorKaefer, Igor L.pt_BR
dc.contributor.authorGrazziotin, Felipe Gobbipt_BR
dc.contributor.authorFan, Hui Wenpt_BR
dc.contributor.authorMoura-da-Silva, Ana Mariapt_BR
dc.date.accessioned2020-07-09T21:26:30Z-
dc.date.available2020-07-09T21:26:30Z-
dc.date.issued2020pt_BR
dc.identifier.citationMonteiro WM, Contreras-Bernal JC, Ferreira Bisneto P, Sachett J, Silva IM, Lacerda M, et al. Bothrops atrox, the most important snake involved in human envenomings in the amazon: how venomics contributes to the knowledge of snake biology and clinical toxinology. Toxicon X. 2020 Jun;6:100037. doi:10.1016/j.toxcx.2020.100037.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2939-
dc.description.abstractBothrops atrox snakes are mostly endemic of the Amazon rainforest and is certainly the South American pit viper responsible for most of the snakebites in the region. The composition of B. atrox venom is significantly known and has been used to trace the relevance of the venom phenotype for snake biology and for the impacts in the clinics of human patients involved in accidents by B. atrox. However, in spite of the wide distribution and the great medical relevance of B. atrox snakes, B. atrox taxonomy is not fully resolved and the impacts of the lack of taxonomic resolution on the studies focused on venom or envenoming are currently unknown. B. atrox venom presents different degrees of compositional variability and is generally coagulotoxic, inducing systemic hematological disturbances and local tissue damage in snakebite patients. Antivenoms are the effective therapy for attenuating the clinical signs. This review brings a comprehensive discussion of the literature concerning B. atrox snakes encompassing from snake taxonomy, diet and venom composition, towards clinical aspects of snakebite patients and efficacy of the antivenoms. This discussion is highly supported by the contributions that venomics and antivenomics added for the advancement of knowledge of B. atrox snakes, their venoms and the treatment of accidents they evokept_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent100037pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxicon Xpt_BR
dc.rightsOpen Accesspt_BR
dc.titleBothrops atrox, the most important snake involved in human envenomings in the amazon: how venomics contributes to the knowledge of snake biology and clinical toxinologypt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.toxcx.2020.100037pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.toxcx.2020.100037pt_BR
dc.contributor.externalUniversidade do Estado do Amazonas (UEA)¦¦Brasilpt_BR
dc.contributor.externalFundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal do Amazonas (UFAM)¦¦Brasilpt_BR
dc.contributor.externalFundação Alfredo da Matta (FUAM)¦¦Brasilpt_BR
dc.contributor.externalFundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal do Acre (UFAC)¦¦Brasilpt_BR
dc.contributor.externalInstituto Leônidas & Maria Deane (ILMD/Fiocruz Amazônia)¦¦Brasilpt_BR
dc.identifier.citationvolume6pt_BR
dc.subject.keywordCommon lanceheadpt_BR
dc.subject.keywordEnvenomingpt_BR
dc.subject.keywordVenomicspt_BR
dc.subject.keywordAntivenomicspt_BR
dc.subject.keywordAntivenompt_BR
dc.subject.keywordViperidaept_BR
dc.subject.keywordSnakebitept_BR
dc.subject.keywordPit viperpt_BR
dc.relation.ispartofabbreviatedToxicon Xpt_BR
dc.identifier.citationabntv. 6, 100037, jun. 2020pt_BR
dc.identifier.citationvancouver2020 Jun;6:100037pt_BR
dc.contributor.butantanGrazziotin, Felipe Gobbi|:Pesquisador:Docente Colaborador PPGTOX|:Laboratório Especial de Toxinologia Aplicada (LETA)|:pt_BR
dc.contributor.butantanFan, Hui Wen|:Pesquisador|:Laboratório de Artrópodes|:pt_BR
dc.contributor.butantanMoura-da-Silva, Ana Maria|:Docente Permanente PPGTOX|:Lab. Imunopatologia|:Autor de correspondênciapt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦2992/2014pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/50,127–5pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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