The interplay between host haemostatic systems and Leptospira spp. infections

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dc.contributorLaboratório de Desenvolvimento de Vacinaspt_BR
dc.contributor.authorVieira, Mônica Laruccipt_BR
dc.contributor.authorHerwald, Heikopt_BR
dc.contributor.authorNascimento, Ana Lúcia Tabet Oller dopt_BR
dc.date.accessioned2020-07-09T21:26:48Z-
dc.date.available2020-07-09T21:26:48Z-
dc.date.issued2020pt_BR
dc.identifier.citationVieira ML, Herwald H, Nascimento ALTO. The interplay between host haemostatic systems and Leptospira spp. infections. Crit. Rev. Microbiol.. 2020 Mar;46(2):121-135. doi:10.1080/1040841X.2020.1735299.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2964-
dc.description.abstractHemostasis is a defence mechanism that protects the integrity of the vascular system and is comprised of the coagulation cascade, fibrinolysis, platelet aggregation, and vascular endothelium. Besides the primary function in preserving the vascular integrity, the haemostatic system cooperates with immune and inflammatory processes to eliminate invading pathogens during microbial infections. Under pathological manifestations, hemostasis must therefore interact in a coordinated manner with inflammatory responses and immune reactions. Several pathogens can modulate these host-derived countermeasures by specifically targeting certain haemostatic components for their own benefit. Thus, the ability to modulate host defence systems has to be considered as an essential bacterial virulence mechanism. Complications that bacterial pathogens can induce are therefore often the consequence of evoked host responses. A comprehensive understanding of the molecular mechanisms triggered in infectious processes may help to develop prophylactic methods and novel therapies for the patients suffering from a particular infectious disease. This review aims to provide a critical updated compiling of recent studies on how the pathogenic Leptospira can interact with and manipulate the host haemostatic systems and the consequences for leptospirosis pathogenesis.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.format.extent121-135pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofCritical Reviews In Microbiologypt_BR
dc.titleThe interplay between host haemostatic systems and Leptospira spp. infectionspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1080/1040841X.2020.1735299pt_BR
dc.identifier.urlhttps://doi.org/10.1080/1040841X.2020.1735299pt_BR
dc.contributor.externalUniversidade Federal de Minas Gerais (UFMG)¦¦Brasilpt_BR
dc.contributor.externalLunds Universitet¦¦Suéciapt_BR
dc.identifier.citationvolume46pt_BR
dc.identifier.citationissue2pt_BR
dc.subject.keywordLeptospirosispt_BR
dc.subject.keywordhost–pathogen interactionspt_BR
dc.subject.keywordhemostasispt_BR
dc.subject.keywordinfectious diseasespt_BR
dc.subject.keywordcoagulationpt_BR
dc.relation.ispartofabbreviatedCrit Rev Microbiolpt_BR
dc.identifier.citationabntv. 46, n. 2, p. 121-135, mar. 2020pt_BR
dc.identifier.citationvancouver2020 Mar;46(2):121-135pt_BR
dc.contributor.butantanNascimento, Ana Lúcia Tabet Oller do|:Pesquisador|:Laboratório de Desenvolvimento de Vacinas|:pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/00236-5pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/50981-0pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
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