Involvement of the Hsp70/TLR4/IL-6 and TNF-α pathways in delayed-onset muscle soreness

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dc.contributorLaboratório de Dor e Sinalizaçãopt_BR
dc.contributor.authorSantos, Rafaela Silva dospt_BR
dc.contributor.authorVeras, Flávio Protasiopt_BR
dc.contributor.authorFerreira, David Wilsonpt_BR
dc.contributor.authorSant´Anna, Morena Brazil Martinspt_BR
dc.contributor.authorLollo, Pablo Christiano Barbozapt_BR
dc.contributor.authorCunha, Thiago Mattarpt_BR
dc.contributor.authorGaldino, Giovanept_BR
dc.date.accessioned2020-07-09T21:26:55Z-
dc.date.available2020-07-09T21:26:55Z-
dc.date.issued2020pt_BR
dc.identifier.citationSantos RS, Veras FP, Ferreira DW, Sant´Anna MBM, Lollo PCB, Cunha TM, et al. Involvement of the Hsp70/TLR4/IL-6 and TNF-α pathways in delayed-onset muscle soreness. J Neurochem. 2020 Oct;155(1):29-44. doi:https://repositorio.butantan.gov.br/handle/butantan/2974.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2974-
dc.description.abstractDelayed-onset muscle soreness (DOMS) is a very common condition in athletes and individuals not accustomed to physical activity that occurs after moderate/high-intensity exercise sessions. Activation of microglial Toll-like receptor 4 (TLR4) in the spinal cord has been described to be important for the induction and maintenance of persistent pain. Based on that, we hypothesize that 70 kilodalton heat shock protein (Hsp70), a mediator released by exercise, could activate microglial TLR4 in the spinal cord, releasing proinflammatory cytokines and contributing to the start of DOMS. In fact, we found that the knockout of TLR4, myeloid differentiation primary response 88 (MyD88), interleukin-6 (IL-6), or both TNF-a receptor 1 (TNFR1) and TNF-a receptor 2 (TNFR2) in mice prevented the development of DOMS following acute aerobic exercise in contrast to the findings in male C57BL/6 wild-type (WT) mice. Furthermore, DOMS in exercised WT mice was also prevented after pretreatment with microglia inhibitor, TLR4 antagonist and anti-Hsp70 antibody. During exercise-induced DOMS, Hsp70 mRNA, TLR4 mRNA and protein levels, as well as Iba-1 (a microglial marker), IL-6 and TNF-a protein levels, were increased in the muscle and/or spinal cord. Together, these findings suggest that Hsp70 released during exercise-induced DOMS activates the microglial TLR4/IL-6/TNF-a pathway in the spinal cord. Thus, the blockade of TLR4 activation may be a new strategy to prevent the development of DOMS before intense exercise.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)pt_BR
dc.format.extentp. 29-44pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofJournal of Neurochemistrypt_BR
dc.titleInvolvement of the Hsp70/TLR4/IL-6 and TNF-α pathways in delayed-onset muscle sorenesspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1111/jnc.15006pt_BR
dc.identifier.urlhttps://doi.org/10.1111/jnc.15006pt_BR
dc.contributor.externalUniversidade Federal de Alfenas (UNIFAL-MG)¦¦Brasilpt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalUniversity of Pittsburgh¦¦Estados Unidospt_BR
dc.contributor.externalUniversidade Federal da Grande Dourados (UFGD)¦¦Brasilpt_BR
dc.identifier.citationvolume155pt_BR
dc.identifier.citationissue1pt_BR
dc.subject.keywordcytokinespt_BR
dc.subject.keywordDOMSpt_BR
dc.subject.keywordexercisept_BR
dc.subject.keywordHsp70pt_BR
dc.subject.keywordnociceptionpt_BR
dc.subject.keywordTLR4pt_BR
dc.relation.ispartofabbreviatedJ Neurochempt_BR
dc.identifier.citationabntv. 155, n. 1, p. :29-44, out. 2020pt_BR
dc.identifier.citationvancouver2020 Oct;155(1):29-44pt_BR
dc.contributor.butantanSant'Anna, Morena Brazil Martins|:Aluno|:Laboratório de Dor e Sinalização|:pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
item.fulltextCom Texto completo-
item.openairetypeArticle-
item.grantfulltextembargo_29990101-
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