Pic-producing escherichia coli induces high production of proinflammatory mediators by the host leading to death by sepsis

Full metadata record
DC FieldValueLanguage
dc.contributorLaboratório de Bacteriologiapt_BR
dc.contributor.authorDutra, Itaynara L.pt_BR
dc.contributor.authorAraújo, Lorena G.pt_BR
dc.contributor.authorAssunção, Raissa G.pt_BR
dc.contributor.authorLima, Yago A.pt_BR
dc.contributor.authorNascimento, Johnny R.pt_BR
dc.contributor.authorVale, André A. M.pt_BR
dc.contributor.authorAlves, Patrícia C. S.pt_BR
dc.contributor.authorTrovão, Liana O.pt_BR
dc.contributor.authorSantos, Ana Carolina M.pt_BR
dc.contributor.authorSilva, Rosa M.pt_BR
dc.contributor.authorSilva, Lucilene A.pt_BR
dc.contributor.authorMaciel, Márcia C. G.pt_BR
dc.contributor.authorSousa, Eduardo M. dept_BR
dc.contributor.authorElias, Waldir Pereirapt_BR
dc.contributor.authorNascimento, Flávia R. F.pt_BR
dc.contributor.authorAbreu, Afonso G.pt_BR
dc.date.accessioned2020-07-09T21:27:02Z-
dc.date.available2020-07-09T21:27:02Z-
dc.date.issued2020-
dc.identifier.citationDutra IL., Araújo LG., Assunção RG., Lima YA., Nascimento JR., Vale AA.M., et al. Pic-producing escherichia coli induces high production of proinflammatory mediators by the host leading to death by sepsis. Int. J. Mol. Sci.. 2020 Mar;21(6):2068. doi:10.3390/ijms21062068.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2984-
dc.description.abstractEscherichia coli is an important pathogen responsible for a variety of diseases. We have recently shown that Pic, a serine protease secreted by E. coli, mediates immune evasion by the direct cleavage of complement molecules. The aim of this study was to investigate the action of a Pic-producing bacteria in a murine model of sepsis. Mice were infected with Pic-producing E. coli (F5) or F5?pic mutant. Animal survival was monitored for five days, and a subset of mice was euthanized after 12 h for sample acquisition. The inoculation of Pic-producing bacteria induced 100% death within 24 h. The colony forming units count in the organs was significantly higher in F5. Hematological analysis showed a decrease of total leukocytes. Nitric oxide and cytokines were detected in serum, as well as on peritoneal lavage of the F5 group in higher levels than those detected in the other groups. In addition, immunophenotyping showed a decrease of activated lymphocytes and macrophages in the F5 group. Therefore, Pic represents an important virulence factor, allowing the survival of the bacterium in the bloodstream and several organs, as well as inducing a high production of proinflammatory mediators by the host, and concomitantly a cellular immunosuppression, leading to sepsis and deathpt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão (FAPEMA)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipInstituto Estadual de Ciência, Tecnologia e Inovação do Maranhão (IECT)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent2068pt_BR
dc.languageengpt_BR
dc.relation.ispartofInternational Journal of Molecular Sciencespt_BR
dc.rightsOpen Accesspt_BR
dc.titlePic-producing escherichia coli induces high production of proinflammatory mediators by the host leading to death by sepsispt_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/ijms21062068pt_BR
dc.identifier.urlhttps://doi.org/10.3390/ijms21062068pt_BR
dc.contributor.externalUniversidade Ceuma¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal do Maranhão (UFMA)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal de São Paulo (UNIFESP)¦¦Brasilpt_BR
dc.contributor.externalUniversidade de Brasília (UNB)¦¦Brasilpt_BR
dc.identifier.citationvolume21pt_BR
dc.identifier.citationissue6pt_BR
dc.subject.keywordEscherichia colipt_BR
dc.subject.keywordPicpt_BR
dc.subject.keywordserine proteasept_BR
dc.subject.keywordvirulencept_BR
dc.subject.keywordsepsispt_BR
dc.relation.ispartofabbreviatedInt. J. Mol. Sci.pt_BR
dc.identifier.citationabntv. 21, n. 6, 2068, mar. 2020pt_BR
dc.identifier.citationvancouver2020 Mar;21(6):2068pt_BR
dc.contributor.butantanElias, Waldir Pereira|:Pesquisador|:Laboratório de Bacteriologia|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão (FAPEMA)¦¦pt_BR
dc.sponsorship.butantanInstituto Estadual de Ciência, Tecnologia e Inovação do Maranhão (IECT)¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextembargo_29990101-
crisitem.journal.journalissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journaleissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
Appears in Collections:Artigos de periódicos

Files in This Item:
File SizeFormat Existing users please Login
10.3390ijms21062068.pdf3.51 MBAdobe PDFEmbargoed until January 1, 2999    Request a copy
Show simple item record

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.