Role of aspirin-triggered lipoxin A4, aspirin, and salicylic acid in the modulation of the oxidative and inflammatory responses induced by plasma from women with pre-eclampsia

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dc.contributorCENTD - Centro de Excelência para Descoberta de Alvos Molecularespt_BR
dc.contributor.authorGil-Villa, Aura Maríapt_BR
dc.contributor.authorGómez, Angela María Alvarezpt_BR
dc.contributor.authorVelásquez-Berrío, Manuelapt_BR
dc.contributor.authorRojas-López, Mauriciopt_BR
dc.contributor.authorCadavid J, Angela P.pt_BR
dc.date.accessioned2020-07-09T21:27:45Z-
dc.date.available2020-07-09T21:27:45Z-
dc.date.issued2020pt_BR
dc.identifier.citationGil-Villa AM, Alvarez AM, Velásquez-Berrío M, Rojas-López M, Cadavid J AP.. Role of aspirin-triggered lipoxin A4, aspirin, and salicylic acid in the modulation of the oxidative and inflammatory responses induced by plasma from women with pre-eclampsia. Am. J. Reprod. Immunol.. 2020 Feb;83:e13207. doi:10.1111/aji.13207.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3037-
dc.description.abstractProblem Oxidative stress and inflammation are key events leading to pre-eclampsia, involved in several maternal deaths. Low doses of acetylsalicylic acid (ASA) are used in the prevention and treatment of pre-eclampsia. The synthesis of aspirin-triggered lipoxin (ATL) by cyclooxygenase-2 acetylation is an alternative mechanism of ASA, which could explain the effectiveness of ASA treatments. The aim of this study was to evaluate the role of ASA, salicylates, and ATL in the modulation of the oxidative and inflammatory responses induced by plasma from women with pre-eclampsia. Method of study Plasma from 14 women with pre-eclampsia and 17 normotensive pregnant women was probed for inducing oxidative and inflammatory responses on endothelial cells and U937 promonocytes. The role of ATL, ASA, and salicylic acid (SA) on these events was evaluated. Results Plasma from women with pre-eclampsia induced TBARS and nitrotyrosine production on endothelial and U937 cells. Pre-treatment with both ATL and ASA decreased the TBARS production, while ATL decreased the nitrotyrosine. Pre-eclamptic plasma augmented the translocation of NF-kB on U937 cells, which decreased by a high dose of ASA and SA. Finally, the pre-eclamptic plasma increased the adhesion of leukocytes—PMN and monocytes—to endothelium, and we were able to determine a state of resolution of inflammation, since ATL decreased the PMN adhesion, and conversely, it increased the monocytes adhesion to endothelium. Conclusion Together, these results suggest that ATL could explain the beneficial actions of ASA and support further research on mechanisms, real efficacy, and rational use of ASA in pre-eclampsia.pt_BR
dc.description.sponsorshipAdministrative Department of Science and Technology and Innovation (COLCIENCIAS)pt_BR
dc.format.extente13207pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofAmerican Journal of Reproductive Immunologypt_BR
dc.titleRole of aspirin-triggered lipoxin A4, aspirin, and salicylic acid in the modulation of the oxidative and inflammatory responses induced by plasma from women with pre-eclampsiapt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1111/aji.13207pt_BR
dc.identifier.urlhttps://doi.org/10.1111/aji.13207pt_BR
dc.contributor.externalUniversidad de Antioquia (UDEA)¦¦Colômbiapt_BR
dc.contributor.externalRed Iberoamericana de Alteraciones Vasculares Asociadas a Transtornos del Embarazo (RIVA-TREM)¦¦Chilept_BR
dc.identifier.citationvolume83pt_BR
dc.subject.keywordacetylsalicylic acidpt_BR
dc.subject.keywordaspirin-triggered lipoxinspt_BR
dc.subject.keywordinflammationpt_BR
dc.subject.keywordoxidative stresspt_BR
dc.subject.keywordpre-eclampsiapt_BR
dc.subject.keywordsalicylic acidpt_BR
dc.relation.ispartofabbreviatedAm J Reprod Immunolpt_BR
dc.identifier.citationabntv. 83, e13207, fev. 2020pt_BR
dc.identifier.citationvancouver2020 Feb;83:e13207pt_BR
dc.contributor.butantanAlvarez, Angela María|:Aluno|:CENTD - Centro de Excelência para Descoberta de Alvos Moleculares|:Autor de correspondênciapt_BR
dc.sponsorship.butantanAdministrative Department of Science and Technology and Innovation (COLCIENCIAS)¦¦1115-408-20531pt_BR
dc.sponsorship.butantanAdministrative Department of Science and Technology and Innovation (COLCIENCIAS)¦¦757-2017pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextembargo_29990102-
item.languageiso639-1English-
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