Analysis of the virulence profile and phenotypic features of typical and atypical enteroaggregative escherichia coli (EAEC) isolated from diarrheal patients in Brazil

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dc.contributorLab. Bacteriologiapt_BR
dc.contributor.authorDias, Regiane C. B.pt_BR
dc.contributor.authorTanabe, Rodrigo H. S.pt_BR
dc.contributor.authorVieira, Melissa A.pt_BR
dc.contributor.authorCergole-Novella, Maria C.pt_BR
dc.contributor.authorSantos, Luis F. dospt_BR
dc.contributor.authorGomes, Tânia A. T.pt_BR
dc.contributor.authorElias, Waldir Pereirapt_BR
dc.contributor.authorHernandes, Rodrigo T.pt_BR
dc.date.accessioned2020-07-09T21:27:47Z-
dc.date.available2020-07-09T21:27:47Z-
dc.date.issued2020pt_BR
dc.identifier.citationDias RC.B., Tanabe RH.S., Vieira MA., Cergole-Novella MC., Santos LF., Gomes TA.T., et al. Analysis of the virulence profile and phenotypic features of typical and atypical enteroaggregative escherichia coli (EAEC) isolated from diarrheal patients in Brazil. Front. Cell. Infect. Microbiol.. 2020 Apr;10:144. doi:10.3389/fcimb.2020.00144.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3040-
dc.description.abstractEnteroaggregative Escherichia coli (EAEC) is an important agent of acute and persistent diarrhea in children and adults worldwide. Here we report a characterization of 220 EAEC isolates, 88.2% (194/220) of which were typical and 11.8% (26/220) were atypical, obtained from diarrheal patients during seven years (2010-2016) of epidemiological surveillance in Brazil. The majority of the isolates were assigned to phylogroups A (44.1%, 97/220) or B1 (21.4%, 47/220). The aggregative adherence (AA) pattern was detected in 92.7% (204/220) of the isolates, with six of them exhibiting AA concomitantly with a chain-like adherence pattern; and agg5A and agg4A were the most common adhesin-encoding genes, which were equally detected in 14.5% (32/220) of the isolates. Each of 12 virulence factor-encoding genes (agg4A, agg5A, pic, aap, aaiA, aaiC, aaiG, orf3, aar, air, capU, and shf) were statistically associated with typical EAEC (P < 0.05). The genes encoding the newly described aggregate-forming pili (AFP) searched (afpB, afpD, afpP, and afpA2), and/or its regulator (afpR), were exclusively detected in atypical EAEC (57.7%, 15/26), and showed a significant association with this subgroup of EAEC (P < 0.001). In conclusion, we presented an extensive characterization of the EAEC circulating in the Brazilian settings and identified the afp genes as putative markers for increasing the efficiency of atypical EAEC diagnosis.pt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.extent144pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofFrontiers in Cellular and Infection Microbiologypt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleAnalysis of the virulence profile and phenotypic features of typical and atypical enteroaggregative escherichia coli (EAEC) isolated from diarrheal patients in Brazilpt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3389/fcimb.2020.00144pt_BR
dc.identifier.urlhttps://doi.org/10.3389/fcimb.2020.00144pt_BR
dc.contributor.externalUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP)¦¦Brasilpt_BR
dc.contributor.externalInstituto Adolfo Lutz (IAL)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal de São Paulo (UNIFESP)¦¦Brasilpt_BR
dc.identifier.citationvolume10pt_BR
dc.subject.keywordEAECpt_BR
dc.subject.keywordvirulence factorspt_BR
dc.subject.keyworddiarrheapt_BR
dc.subject.keyworddiagnosispt_BR
dc.subject.keywordantimicrobialpt_BR
dc.subject.keywordresistancept_BR
dc.relation.ispartofabbreviatedFront Cell Infect Microbiolpt_BR
dc.identifier.citationabntv. 10, 144, abr. 2020pt_BR
dc.identifier.citationvancouver2020 Apr;10:144pt_BR
dc.contributor.butantanElias, Waldir Pereira|:Pesquisador|:Lab. Bacteriologia|:pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦001pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦0708/2018pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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item.languageiso639-1English-
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