Virulence potential of a multidrug-resistant escherichia coli strain belonging to the emerging clonal group ST101-B1 isolated from bloodstream infection

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dc.contributorLETA - Laboratório de Toxinologia Aplicadapt_BR
dc.contributorLab. Bacteriologiapt_BR
dc.contributor.authorSantos, Ana Carolina M.pt_BR
dc.contributor.authorSilva, Rosa M.pt_BR
dc.contributor.authorValiatti, Tiago B.pt_BR
dc.contributor.authorSantos, Fernanda F.pt_BR
dc.contributor.authorSantos-Neto, José F.pt_BR
dc.contributor.authorCayô, Rodrigopt_BR
dc.contributor.authorStreling, Ana P.pt_BR
dc.contributor.authorNodari, Carolina S.pt_BR
dc.contributor.authorGales, Ana C.pt_BR
dc.contributor.authorNishiyama Junior, Milton Yutakapt_BR
dc.contributor.authorCarvalho, Eneaspt_BR
dc.contributor.authorGomes, Tânia A. T.pt_BR
dc.date.accessioned2020-07-09T21:27:59Z-
dc.date.available2020-07-09T21:27:59Z-
dc.date.issued2020pt_BR
dc.identifier.citationSantos ACM., Silva RM., Valiatti TB., Santos FF., Santos-Neto JF., Cayô R, et al. Virulence potential of a multidrug-resistant escherichia coli strain belonging to the emerging clonal group ST101-B1 isolated from bloodstream infection. Microorganisms. 2020 May;8(6):827. doi:10.3390/microorganisms8060827.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3057-
dc.description.abstractEscherichia coli EC121 is a multidrug-resistant (MDR) strain isolated from a bloodstream infection of an inpatient with persistent gastroenteritis and T-zone lymphoma that died due to septic shock. Despite causing an extraintestinal infection, previous studies showed that it did not have the usual characteristics of an extraintestinal pathogenic E. coli. Instead, it belonged to phylogenetic group B1 and harbored few known virulence genes. To evaluate the pathogenic potential of strain EC121, an extensive genome sequencing and in vitro characterization of various pathogenicity-associated properties were performed. The genomic analysis showed that strain EC121 harbors more than 50 complete virulence genetic clusters. It also displays the capacity to adhere to a variety of epithelial cell lineages and invade T24 bladder cells, as well as the ability to form biofilms on abiotic surfaces, and survive the bactericidal serum complement activity. Additionally, EC121 was shown to be virulent in the Galleria mellonella model. Furthermore, EC121 is an MDR strain harboring 14 antimicrobial resistance genes, including blaCTX-M-2. Completing the scenario, it belongs to serotype O154:H25 and to sequence type 101-B1, which has been epidemiologically linked to extraintestinal infections as well as to antimicrobial resistance spread. This study with E. coli strain EC121 shows that clinical isolates considered opportunistic might be true pathogens that go underestimated.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent827pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofMicroorganismspt_BR
dc.rightsOpen Accesspt_BR
dc.titleVirulence potential of a multidrug-resistant escherichia coli strain belonging to the emerging clonal group ST101-B1 isolated from bloodstream infectionpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/microorganisms8060827pt_BR
dc.identifier.urlhttps://doi.org/10.3390/microorganisms8060827pt_BR
dc.contributor.externalUniversidade Federal de São Paulo (UNIFESP)¦¦Brasilpt_BR
dc.identifier.citationvolume8pt_BR
dc.identifier.citationissue6pt_BR
dc.subject.keywordEscherichia colipt_BR
dc.subject.keywordextraintestinalpt_BR
dc.subject.keywordintestinalpt_BR
dc.subject.keywordmultidrug resistancept_BR
dc.subject.keywordhybrid pathogenpt_BR
dc.subject.keywordbloodstream infectionpt_BR
dc.subject.keywordDECpt_BR
dc.subject.keywordMDRpt_BR
dc.subject.keywordvirulencept_BR
dc.subject.keywordST101pt_BR
dc.relation.ispartofabbreviatedMicroorganismspt_BR
dc.identifier.citationabntv. 8, n. 6, 827, mai. 2020pt_BR
dc.identifier.citationvancouver2020 May;8(6):827pt_BR
dc.contributor.butantanNishiyama Junior, Milton Yutaka|:Pesquisador|:Laboratório Especial de Toxinologia Aplicada (LETA)|:pt_BR
dc.contributor.butantanCarvalho, Eneas|:Pesquisador|:Lab. Bacteriologia|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦305535/2014-5pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦001pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦88882.306532/2018-01pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦16/01656-5pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦: 2009/00402-6pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2018/17353-7pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/21947-7pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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