Pets in peril: the relative susceptibility of cats and dogs to procoagulant snake venoms

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dc.contributorLaboratório de Imunopatologiapt_BR
dc.contributor.authorZdenek, Christina N.pt_BR
dc.contributor.authorLlinas, Joshuapt_BR
dc.contributor.authorDobson, Jamespt_BR
dc.contributor.authorAllen, Lukept_BR
dc.contributor.authorDunstan, Nathanpt_BR
dc.contributor.authorSousa, Leijiane Figueira dept_BR
dc.contributor.authorMoura-da-Silva, Ana Mariapt_BR
dc.contributor.authorFry, Bryan G.pt_BR
dc.date.accessioned2020-08-25T20:06:15Z-
dc.date.available2020-08-25T20:06:15Z-
dc.date.issued2020-
dc.identifier.citationZdenek CN., Llinas J, Dobson J, Allen L, Dunstan N, Sousa LF, et al. Pets in peril: the relative susceptibility of cats and dogs to procoagulant snake venoms. Comp. Biochem. Physiol. C. Toxicol. Pharmacol.. 2020 Oct;236:108769. doi:10.1016/j.cbpc.2020.108769.pt_BR
dc.identifier.issn1532-0456-
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3142-
dc.description.abstractSnakebite is a common occurrence for pet cats and dogs worldwide and can be fatal. In Australia the eastern brown snake (Pseudonaja textilis) is responsible for an estimated 76% of reported snakebite cases to domestic pets nationally each year, with the primary pathology being venom-induced consumptive coagulopathy. While only 31% of dogs survive P. textilis bites without antivenom, cats are twice as likely to survive bites (66%). Even with antivenom treatment, cats have a significantly higher survival rate. The reason behind this disparity is unclear. Using a coagulation analyser (Stago STA R Max), we tested the relative procoagulant effects of P. textilis venom—as well as 10 additional procoagulant venoms found around the world—on cat and dog plasma in vitro, as well as on human plasma for comparison. All venoms acted faster upon dog plasma than cat or human, indicating that dogs would likely enter coagulopathic states sooner, and are thus more vulnerable to procoagulant snake venoms. The spontaneous clotting time (recalcified plasma with no venom added) was also substantially faster in dogs than in cats, suggesting that the naturally faster clotting blood of dogs predisposes them to being more vulnerable to procoagulant snake venoms. This is consistent with clinical records showing more rapid onset of symptoms and lethal effects in dogs than cats. Several behavioural differences between cats and dogs are also highly likely to disproportionately negatively affect prognosis in dogs. Thus, compared to cats, dogs require earlier snakebite first-aid and antivenom to prevent the onset of lethal venom effects.pt_BR
dc.description.sponsorshipAustralian Research Council (ARC)pt_BR
dc.format.extent108769pt_BR
dc.languageengpt_BR
dc.publisherElsevier Sciencept_BR
dc.relation.ispartofComparative Biochemistry and Physiology Part C: Toxicology & Pharmacologypt_BR
dc.titlePets in peril: the relative susceptibility of cats and dogs to procoagulant snake venomspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.cbpc.2020.108769pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.cbpc.2020.108769pt_BR
dc.contributor.externalUniversity of Queensland (UQ)pt_BR
dc.contributor.externalUnusual Pets Vetspt_BR
dc.contributor.externalVenom Suppliespt_BR
dc.publisher.cityNew Yorkpt_BR
dc.identifier.citationvolume236pt_BR
dc.subject.keywordElapid snake envenomationpt_BR
dc.subject.keywordSnake venompt_BR
dc.subject.keywordSnakebitept_BR
dc.subject.keywordDogspt_BR
dc.subject.keywordCatspt_BR
dc.subject.keywordCoagulotoxinspt_BR
dc.subject.keywordPseudonaja textilispt_BR
dc.subject.keywordClinical toxicologypt_BR
dc.relation.ispartofabbreviatedComp. Biochem. Physiol. C. Toxicol. Pharmacol.pt_BR
dc.identifier.citationabntv. 236, 108769, out. 2020pt_BR
dc.identifier.citationvancouver2020 Oct;236:108769pt_BR
dc.publisher.countryUnited Statespt_BR
dc.contributor.butantanMoura-da-Silva, Ana Maria|:Pesquisador:Docente permanente PPGTOX|:Laboratório de Imunopatologiapt_BR
dc.contributor.butantanSousa, Leijiane Figueira de|:Aluno|:Laboratório de Imunopatologiapt_BR
dc.sponsorship.butantanAustralian Research Council (ARC)¦¦DP190100304pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextembargo_29990101-
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